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A Critical Role of Basolateral Amygdala to Nucleus Accumbens Projection in Sleep Regulation of Reward Seeking
Biological Psychiatry ( IF 11.501 ) Pub Date : 2019-11-09 , DOI: 10.1016/j.biopsych.2019.10.027
Yao Wang, Zheng Liu, Li Cai, Rong Guo, Yan Dong, Yanhua H. Huang

Background Sleep impacts reward-motivated behaviors partly by retuning the brain reward circuits. The nucleus accumbens (NAc) is a reward processing hub sensitive to acute sleep deprivation. Glutamatergic transmission carrying reward-associated signals converges in the NAc and regulates various aspects of reward-motivated behaviors. The basal lateral amygdala projection (BLAp) innervates broad regions of the NAc, and critically regulates reward seeking. Methods Using slice electrophysiology, we measured how acute sleep deprivation alters transmission at BLAp-NAc synapses in male C57BL/6 mice. Moreover, using stabilized step function opsin (SSFO) and DREADDs (Gi) to amplify and reduce transmission, respectively, we tested behavioral consequences following bi-directional manipulations of BLAp-NAc transmission. Results Acute sleep deprivation increased sucrose self-administration in mice, and altered the BLAp-NAc transmission in a topographically specific manner. It selectively reduced glutamate release at rostral BLAp (rBLAp) onto ventral and lateral NAc (vlNAc) synapses, but spared caudal BLAp (cBLAp) onto medial NAc (mNAc) synapses. Furthermore, experimentally facilitating glutamate release at rBLAp-vlNAc synapses suppressed sucrose reward seeking. Conversely, mimicking sleep deprivation-induced reduction of rBLAp-vlNAc transmission increased sucrose reward seeking. Finally, facilitating rBLAp-vlNAc transmission per se did not promote either approach-motivation or aversion. Conclusions Sleep acts on rBLAp-vINAc transmission gain control to regulate established reward seeking, but does not convey approach-motivation or aversion on its own.
更新日期:2019-11-11

 

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