BODIPY is an important fluorophores due to its enhanced photophysical and chemical properties including outstanding thermal/photochemical stability, intense absorption/emission profiles, high photoluminescence quantum yield, and small Stokes' shifts. In addition to BODIPY, indole and its derivatives have recently gained attention because of their structural properties and particularly biological importance, therefore these molecules have been widely used in sensing and biosensing applications. Here, we focus on recent studies that reported the incorporation of indole-based BODIPY molecules as reporter molecules in sensing systems. We highlight the rationale for developing such systems and evaluate detection limits of the developed sensing platforms. Furthermore, we also review the application of indole-based BODIPY molecules in bioimaging studies. This article includes the evaluation of indole-based BODIPYs from synthesis to characterization and a comparison of the advantages and disadvantages of developed reporter systems, making it instructive for researchers in various disciplines for the design and development of similar systems.

中文翻译：

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最近基于吲哚修饰的BODIPY的化学/生物传感器和生物成像研究。

BODIPY是重要的荧光团，因为它具有增强的光物理和化学特性，包括出色的热/光化学稳定性，强烈的吸收/发射曲线，高的光致发光量子产率和小的斯托克斯位移。除了BODIPY以外，由于它们的结构特性，尤其是生物学重要性，吲哚及其衍生物最近也受到关注，因此这些分子已广泛用于传感和生物传感应用中。在这里，我们专注于最近的研究，这些研究报告了将基于吲哚的BODIPY分子作为报告分子掺入传感系统中。我们重点介绍了开发此类系统的原理，并评估了已开发的传感平台的检测极限。此外，我们还回顾了基于吲哚的BODIPY分子在生物成像研究中的应用。本文包括对从合成到表征的基于吲哚的BODIPY的评估，以及对已开发的报道系统的优缺点的比较，这对于不同学科的研究人员对类似系统的设计和开发具有指导意义。