Understanding human development has fascinated scientists for centuries. With advancements in stem cell technologies, this understanding has expanded beyond fascination to application towards informing the design of therapeutics in regenerative medicine. A focus on establishing a better grasp of the physicochemical cues governing differentiation and tissue assembly has continually enhanced engineered systems to an unprecedented level of biomimicry and, in doing so, has allowed the design of novel therapeutics. The vasculature has a critical role during early stages of development and regeneration events, and is responsive to a range of dynamic environmental cues. In this review, we present biomaterials systems capable of spatially and temporally controlling environmental signals that guide vascular fate and assembly, thereby further informing our understanding of differentiation schema.

中文翻译：

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体外重建血管发育环境。

几个世纪以来，对人类发展的了解使科学家着迷。随着干细胞技术的进步，这种理解已经从迷恋扩展到了向再生医学的治疗药物设计提供信息的应用。对更好地掌握控制分化和组织组装的物理化学线索的关注已将工程系统不断增强，达到了前所未有的仿生水平，并且通过这种方式，可以设计出新颖的疗法。脉管系统在发育和再生事件的早期阶段起着至关重要的作用，并且对一系列动态环境线索做出响应。在这篇评论中，我们介绍了能够在空间和时间上控制环境信号的生物材料系统，这些信号指导着血管的命运和组装，