A simple, catalyst-free, straightforward, and highly efficient synthesis of pharmaceutically interesting diverse perfluoroalkylated cis-spiropyrimidine-5,1'-quinolizines and pyrano[2,3-d]pyrimidines has been developed based on a three component reaction between 5-arylidenebarbituric acids 1, methyl perfluoroalk-2-ynoates 2, and pyridines 3 in MeCN at -10 °C or 65 °C. The salient features of this protocol are mild reaction conditions, use of no catalyst, short reaction time, a simple operation and good to excellent yields.

中文翻译：

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无催化剂的全氟烷基化顺式-螺嘧啶-5,1'-喹啉和吡喃并[2,3- d ]嘧啶的无催化剂合成

基于5-之间的三组分反应，开发了一种简单，无催化剂，简单且高效的药物学上令人感兴趣的全氟烷基化顺式-螺嘧啶-5,1'-喹啉和吡喃并[2,3- d ]嘧啶的合成方法。-10°C或65°C下的MeCN中的亚芳基巴比妥酸1，全氟烷基-2-酸甲酯2和吡啶3。该方案的显着特征是反应条件温和，不使用催化剂，反应时间短，操作简单且收率良好。