The role of systems biology in developing non-model cyanobacteria as hosts for chemical production.,Current Opinion in Biotechnology

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The role of systems biology in developing non-model cyanobacteria as hosts for chemical production.
Current Opinion in Biotechnology ( IF 7.1 ) Pub Date : 2019-11-09 , DOI: 10.1016/j.copbio.2019.10.003
Bratati Mukherjee ₁ , Swati Madhu ₂ , Pramod P Wangikar ₃

Affiliation

Cyanobacteria, a group of photosynthetic prokaryotes, can be engineered for direct conversion of carbon dioxide to value added products. Despite two decades of progress in the metabolic engineering of these photoautotrophs, the reported productivities are below those needed for commercialization. While much of this work has been performed with a handful of model cyanobacteria, new fast-growing and robust cyanobacterial strains may afford significant improvements in productivity. The focus now is on isolating and developing cyanobacteria that can be deployed as industrial strains for the production of a wide range of chemicals. Systems-level characterization, development of synthetic biology tools and improvement in photosynthetic efficiency would be an integral part of host engineering efforts. The knowledge base that exists for model cyanobacteria together with the systems biology data from newer strains will provide the foundation for the development of new hosts.

中文翻译：

系统生物学在开发非模型蓝细菌中作为化学生产宿主的作用。

蓝细菌是一组光合作用的原核生物，可以进行工程设计以将二氧化碳直接转化为增值产品。尽管这些光合自养生物的代谢工程学已取得了二十年的进步，但所报道的生产率仍低于商业化所需的生产率。尽管大部分工作都是使用少数几种蓝细菌模型完成的，但新的快速生长且健壮的蓝细菌菌株可能会显着提高生产率。现在的重点是分离和开发蓝细菌，这些蓝细菌可以用作生产各种化学品的工业菌株。系统级的表征，合成生物学工具的开发以及光合作用效率的提高将是宿主工程工作不可或缺的一部分。

更新日期：2019-11-11

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