Quantitative analysis of glycine related metabolic pathways for one-carbon synthetic biology.,Current Opinion in Biotechnology

当前位置： X-MOL 学术 › Curr. Opin. Biotech. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Quantitative analysis of glycine related metabolic pathways for one-carbon synthetic biology.
Current Opinion in Biotechnology ( IF 7.1 ) Pub Date : 2019-11-09 , DOI: 10.1016/j.copbio.2019.10.001
Yaeseong Hong ₁ , Jie Ren ₂ , Xinyi Zhang ₂ , Wei Wang ₁ , An-Ping Zeng ₃

Affiliation

Glycine is an essential one-carbon (C1) metabolite nested in a complex network of cellular metabolism. Glycine and its related metabolic pathways have important biochemical and biomedical implications and have thus been studied for a long time. However, quantitative and systems level knowledge about the interactions and regulations of the pathways are severely limited, especially for the purpose of reengineering the relevant pathways for C1-based biotechnological processes using synthetic biology and metabolic engineering approaches. In fact, quantitative analytic methods are missing for some of the key players of the glycine-related pathways, prominently the glycine cleavage system and folate cycle, particularly for intracellular processes under physiological conditions. Here, we pinpoint the existing gaps and highlight the need and challenges for future development.

中文翻译：

一碳合成生物学中与甘氨酸相关的代谢途径的定量分析。

甘氨酸是嵌套在复杂的细胞代谢网络中的必不可少的一碳（C1）代谢产物。甘氨酸及其相关的代谢途径具有重要的生化和生物医学意义，因此已经进行了长期的研究。然而，关于途径的相互作用和调控的定量和系统水平的知识受到严格限制，特别是为了使用合成生物学和代谢工程方法重新设计基于C1的生物技术过程的相关途径。实际上，对于甘氨酸相关途径的一些关键因素，尤其是对于在生理条件下的细胞内过程，甘氨酸裂解系统和叶酸循环缺乏定量分析方法。这里，

更新日期：2019-11-11

点击分享查看原文

点击收藏

阅读更多本刊最新论文本刊介绍/投稿指南11