Pancreatic cancer is one of the leading determinants of global cancer mortality, and its incidence is predicted to increase, to become in 2030 the second most common cause of cancer-related death. Obesity and diabetes are recognized risk factors for the development of pancreatic cancer. In the last few decades an epidemic of diabetes and obesity has been spreading worldwide, forewarning an increase in incidence of pancreatic cancer. This review considers the most recent literature, covering the multiple molecular axis linking these three pathologies, aiming to draw a more comprehensive view of pancreatic cancer for a better theragnostic stratification of the population.

中文翻译：

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糖尿病，肥胖与胰腺癌之间的复杂关系。

胰腺癌是全球癌症死亡率的主要决定因素之一，预计其发病率将增加，到2030年将成为癌症相关死亡的第二大最常见原因。肥胖和糖尿病是胰腺癌发展的公认危险因素。在过去的几十年中，糖尿病和肥胖症的流行已在世界范围内蔓延，预示着胰腺癌的发病率将增加。这篇综述考虑了涵盖这三种病理联系的多分子轴的最新文献，目的是对胰腺癌进行更全面的了解，以更好地对人群进行鼻吻合治疗。