Nowadays, nanomaterials have rapidly developed as a new generation of antibacterial agents. However, high local aggregation and concentration, and possible toxicity due to excess leaching are disadvantages of nanoparticles. Unique features of metal–organic frameworks (MOFs) such as coordinately unsaturated centers, high surface area and facile synthesis attracted attention to overcome the above-mentioned problems. In this context, Ag/MIL-101(Cr)/IMI was synthesized, and after characterization by powder X-ray diffraction (XRD), field emission scanning electron microscopy (FE-SEM–EDX), Transmission Electron Microscopy (TEM), Fourier-transform infrared spectroscopy (FTIR), inductively coupled plasma-optical emission spectrometry and BET surface area, TG–DTA was used as an antibacterial agent. Imidazole-functionalized Ag/MIL-101(Cr)/IMI presented a synergistic effect of imidazole and silver NPs against Escherichia coli (ATCC25292) and Staphylococcus aureus (ATCC25293) bacteria. The best antibacterial activity as minimum inhibitory concentration (MIC) was 6.2 µg/mL and 24.78 µg/mL of silver content against E. coli and S. aureus, respectively. There were 81 and 144.9 mg of Ag and imidazole per each gram of Ag/MIL-101(Cr)/IMI, which leaching rates of Ag, imidazole and Cr were 150, 828 and 153 µg/L, respectively. This leaching level of imidazole was lower than the amount recommended by Registry of Toxic Effects of Chemical Substances (RTECS) from NIOSH, while the leaching levels of silver NP and chromium is tended to be around the standard of WHO and U.S.EPA.

如今，纳米材料已迅速发展为新一代抗菌剂。但是，高的局部聚集和浓度以及由于过量浸出而可能产生的毒性是纳米颗粒的缺点。金属有机骨架（MOF）的独特特征（如配位不饱和中心，高表面积和易合成）引起了人们对克服上述问题的关注。在这种情况下，合成了Ag / MIL-101（Cr）/ IMI，并通过粉末X射线衍射（XRD），场发射扫描电子显微镜（FE-SEM-EDX），透射电子显微镜（TEM）进行了表征，傅立叶变换红外光谱（FTIR），电感耦合等离子体发射光谱和BET表面积，TG–DTA被用作抗菌剂。大肠杆菌（ATCC25292）和金黄色葡萄球菌（ATCC25293）细菌。作为最低抑菌浓度（MIC）的最佳抗菌活性分别为对大肠杆菌和金黄色葡萄球菌的银含量为6.2 µg / mL和24.78 µg / mL 。每克Ag / MIL-101（Cr）/ IMI有81和144.9 mg的Ag和咪唑，其中Ag，咪唑和Cr的浸出率分别为150、828和153 µg / L。咪唑的浸出水平低于NIOSH的化学物质毒性作用注册表（RTECS）推荐的量，而银NP和铬的浸出水平往往接近WHO和USEPA的标准。