The progression of ischemic cerebral edema (CE) is closely related to the level of cerebral blood perfusion (CBP) and affects each other. Simultaneous detection of CBP and CE is helpful in understanding the mechanisms of ischemic CE development. In this article, a wide field of view swept‐source optical coherence tomography system was used to detect CE status and CBP levels simultaneously in middle cerebral artery occlusion rats. Images reflecting these two physiological states can be reconstructed with only one C‐scan. We quantify these two physiological states into four parameters, which contain two vascular parameters (vascular displacement distance and vascular perfusion density) and two edema parameters (optical attenuation coefficient and edema area). The association between the two vascular parameters and the two edema parameters was analyzed. The results show that there is a strong linear relationship between blood flow parameters and edema parameters. This work provides a new option for CE in vivo detection, and is very likely to play an important role in the development of relevant drugs or in selection of treatment options.

中文翻译：

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使用扫频光学相干断层扫描技术同时检测脑血流灌注和脑水肿。

缺血性脑水肿（CE）的进展与脑血流灌注（CBP）的水平密切相关，并且相互影响。同时检测CBP和CE有助于了解缺血性CE发生的机制。在本文中，使用了广泛的扫描源光学相干断层扫描系统来同时检测大脑中动脉闭塞大鼠的CE状态和CBP水平。反映这两种生理状态的图像仅需一次C扫描即可重建。我们将这两种生理状态量化为四个参数，其中包含两个血管参数（血管位移距离和血管灌注密度）和两个水肿参数（光学衰减系数和水肿面积）。分析了两个血管参数和两个水肿参数之间的关联。结果表明，血流参数与水肿参数之间存在很强的线性关系。这项工作为CE体内检测提供了新的选择，并且很可能在开发相关药物或选择治疗方案中起重要作用。