Phase-sensitive fluorescence detector for parathyroid glands during thyroidectomy: A preliminary report.,Journal of Biophotonics

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Phase-sensitive fluorescence detector for parathyroid glands during thyroidectomy: A preliminary report.
Journal of Biophotonics ( IF 2.0 ) Pub Date : 2019-11-25 , DOI: 10.1002/jbio.201960078
Yikeun Kim _{1,

2} , Sung Won Kim _{2,

3} , Kang Dae Lee _{2,

3} , Yeh-Chan Ahn _{1,

2}

Affiliation

Despite advances in medical technology, the parathyroid glands are still damaged during thyroid surgery. Our previous studies exploring methods for locating the parathyroid glands using autofluorescence have limitations, such as turning off the surgical light or requiring additional matching between the autofluorescence image and real‐surgical field‐of‐view. We developed a probe‐type parathyroid autofluorescence detector using a phase‐sensitive process and optical filtering to overcome these limitations. A preliminary clinical trial was performed on eight parathyroid glands in four patients. The normalized mean signal of the normal parathyroid glands was 332% stronger than that of the thyroid, and 384%, 459% and 286% stronger than the signal of the muscle, trachea and fat, respectively. Additionally, the device also detected fluorescence from indocyanine green.

中文翻译：

甲状腺切除术中甲状旁腺的相敏荧光检测器：初步报告。

尽管医疗技术有所进步，但甲状旁腺仍在甲状腺手术中受损。我们以前的研究探索了使用自发荧光来定位甲状旁腺的方法的局限性，例如关闭手术灯或需要在自发荧光图像和实际手术视野之间进行其他匹配。我们开发了一种使用相敏过程和光学滤波技术的探针型甲状旁腺自体荧光检测器，以克服这些限制。在四名患者的八个甲状旁腺上进行了一项初步的临床试验。正常甲状旁腺的归一化平均信号比甲状腺强332％，比肌肉，气管和脂肪的信号分别强384％，459％和286％。此外，

更新日期：2019-11-25

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