Expression and phase separation potential of heterochromatin proteins during early mouse development.,EMBO Reports

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Expression and phase separation potential of heterochromatin proteins during early mouse development.
EMBO Reports ( IF 6.5 ) Pub Date : 2019-11-07 , DOI: 10.15252/embr.201947952
Manuel Guthmann _{1,

2} , Adam Burton _{1,

2} , Maria-Elena Torres-Padilla _{1,

2}

Affiliation

In most eukaryotes, constitutive heterochromatin is associated with H3K9me3 and HP1α. The latter has been shown to play a role in heterochromatin formation through liquid-liquid phase separation. However, many other proteins are known to regulate and/or interact with constitutive heterochromatic regions in several species. We postulate that some of these heterochromatic proteins may play a role in the regulation of heterochromatin formation by liquid-liquid phase separation. Indeed, an analysis of the constitutive heterochromatin proteome shows that proteins associated with constitutive heterochromatin are significantly more disordered than a random set or a full nucleome set of proteins. Interestingly, their expression begins low and increases during preimplantation development. These observations suggest that the preimplantation embryo is a useful model to address the potential role for phase separation in heterochromatin formation, anticipating exciting research in the years to come.

中文翻译：

小鼠早期发育过程中异染色质蛋白的表达和相分离潜力。

在大多数真核生物中，组成型异染色质与 H3K9me3 和 HP1α 相关。后者已被证明通过液-液相分离在异染色质形成中发挥作用。然而，已知许多其他蛋白质可调节多个物种的组成型异染色质区域和/或与组成型异染色质区域相互作用。我们假设其中一些异染色质蛋白可能在通过液-液相分离调节异染色质形成中发挥作用。事实上，对组成型异染色质蛋白质组的分析表明，与组成型异染色质相关的蛋白质比随机组或完整核组组的蛋白质更加无序。有趣的是，它们的表达开始较低，并在植入前发育过程中增加。这些观察结果表明，植入前胚胎是一个有用的模型，可以解决相分离在异染色质形成中的潜在作用，预计未来几年将会有令人兴奋的研究。

更新日期：2019-12-05

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