Purpose

Matrix metalloproteinases, zinc dependent proteolytic enzymes, have significant implications in extracellular matrix degradation associated with tissue damage in inflammation and Rheumatoid arthritis. Numerous orchestrated pathways affects instigation and blockade of metalloproteinases as well as various factors that increase the expression of MMPs including inflammatory cytokines, hormones and growth factors. Direct inhibition of these proteolytic enzymes or modulation of these pathways can provide protection against tissue destruction in inflammation and rheumatoid arthritis. Inclination towards use of plant derived phytochemicals to prevent tissue damage has been increasing day by day. Diversity of phytochemicals have been known to directly inhibit metalloproteinases. Hence, thorough knowledge of phytochemicals is very important in novel drug discovery.

Methods

Present communication evaluates various classes of phytochemicals, in effort to unveil the lead molecules as potential therapeutic agents, for prevention of MMPs mediated tissue damage in inflammation and rheumatoid arthritis. Data have been analyzed through different search engines.

Results

Numerous phytochemicals have been studied for their role as MMPs inhibitors which can be processed further to develop into useful drugs for the treatment of inflammation and rheumatoid arthritis.

Conclusion

In search of new drugs, phytochemicals like flavonoids, glycosides, alkaloids, lignans & terpenes offer a wide canvas to develop into valuable forthcoming medicaments.

中文翻译：

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靶向基质金属蛋白酶的植物化学物质，可调节炎症和类风湿关节炎中的组织降解

目的

基质金属蛋白酶，锌依赖性蛋白水解酶，在与炎症和类风湿性关节炎中的组织损伤有关的细胞外基质降解中具有重要意义。许多编排的途径影响金属蛋白酶的激发和阻断，以及各种增加MMPs表达的因素，包括炎性细胞因子，激素和生长因子。这些蛋白水解酶的直接抑制或这些途径的调节可提供针对炎症和类风湿性关节炎中的组织破坏的保护。倾向于使用植物衍生的植物化学物质来防止组织损伤的趋势日益增加。已知多种植物化学物质可直接抑制金属蛋白酶。因此，

方法

当前的通讯评估了各种植物化学物质，以试图揭示铅分子作为潜在的治疗剂，以预防炎症和类风湿性关节炎中MMP介导的组织损伤。数据已通过不同的搜索引擎进行了分析。

结果

已经研究了许多植物化学物质作为MMPs抑制剂的作用，可以进一步加工以发展成用于治疗炎症和类风湿性关节炎的有用药物。

结论

为了寻找新药，类黄酮，糖苷，生物碱，木脂素和萜烯等植物化学物质提供了广阔的前景，可以发展成为有价值的即将到来的药物。