Degassed micromolding lithography for rapid fabrication of anisotropic hydrogel microparticles with high-resolution and high uniformity.,Lab on a Chip

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Degassed micromolding lithography for rapid fabrication of anisotropic hydrogel microparticles with high-resolution and high uniformity.
Lab on a Chip ( IF 6.1 ) Pub Date : 2019-11-08 , DOI: 10.1039/c9lc00828d
Hyeon Ung Kim ₁ , Yong Jun Lim ₁ , Hyun Jee Lee ₁ , Nak Jun Lee ₁ , Ki Wan Bong ₁

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Replica molding techniques, which are used to synthesize microparticles inside anisotropic micromolds, have been developed to enable the mass production of hydrogel particles. However, these techniques are limited in their ability to synthesize only a narrow range of particle compositions and shapes because of the difficulty in loading precursors into the micromolds as well as the low particle homogeneity due to the uneven evaporation of the precursors. Herein, we describe a simple yet powerful technique, called degassed micromolding lithography, which can load precursors within 1 min regardless of the wettability. This technique is based on the gas-solubility of a degassed micromold that acts as a suction pump to completely fill the mold by drawing precursor liquids in. The semi-closed system within the micromold prevents the uneven evaporation of the precursor, which is essential for the production of homogeneous particles. Furthermore, controlled uniformity of the hydrogel microparticles (C.V. < 2%) can be achieved by engineering the design of the micromold array.

中文翻译：

脱气微成型光刻技术，用于快速制备具有高分辨率和高均一性的各向异性水凝胶微粒。

已经开发了用于在各向异性微模具内合成微粒的复制模制技术，以能够大量生产水凝胶颗粒。然而，由于难以将前体装载到微模具中以及由于前体的不均匀蒸发而导致的低颗粒均质性，这些技术在仅合成窄范围的颗粒组成和形状的能力上受到限制。本文中，我们描述了一种简单而强大的技术，称为脱气微成型光刻技术，无论润湿性如何，该技术都可以在1分钟内加载前体。该技术基于脱气的微模的气体溶解度，该微模充当吸力泵，通过吸入前驱液体将其完全填充到模具中。微模具内的半封闭系统可防止前驱体的不均匀蒸发，这对于生产均质颗粒至关重要。此外，通过设计微模具阵列的设计，可以实现水凝胶微粒的受控均匀性（CV <2％）。

更新日期：2019-11-08

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