One hallmark of protein chemical synthesis is its capacity to access proteins that living systems can hardly produce. This is typically the case for proteins harboring post-translational modifications such as ubiquitin or ubiquitin-like modifiers. Various methods have been developed for accessing polyubiquitin conjugates by semi- or total synthesis. Comparatively, the preparation of small-ubiquitin-like modifier (SUMO) conjugates, and more particularly of polySUMO scaffolds, is much less developed. We describe hereinafter a synthetic strategy for accessing all SUMO-2/3 dimer combinations.

中文翻译：

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所有SUMO-2 / 3二聚体组合的总化学合成。

蛋白质化学合成的一个标志是其获得生命系统几乎无法产生的蛋白质的能力。对于带有翻译后修饰的蛋白质（例如泛素或类似泛素的修饰物），通常是这种情况。已经开发了各种方法以通过半合成或全合成来获得多聚泛素结合物。相比之下，小泛素样修饰剂（SUMO）缀合物的制备，尤其是polySUMO支架的制备则远远不够。在下文中，我们描述用于访问所有SUMO-2 / 3二聚体组合的合成策略。