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Prenylated quinolinone alkaloids and prenylated isoindolinone alkaloids from the fungus Aspergillus nidulans
Phytochemistry ( IF 3.2 ) Pub Date : 2020-01-01 , DOI: 10.1016/j.phytochem.2019.112177 Qin Li 1 , Chunmei Chen 1 , Yan He 2 , Mengsha Wei 1 , Li Cheng 3 , Xin Kang 1 , Jianping Wang 1 , Xincai Hao 3 , Hucheng Zhu 1 , Yonghui Zhang 1
Phytochemistry ( IF 3.2 ) Pub Date : 2020-01-01 , DOI: 10.1016/j.phytochem.2019.112177 Qin Li 1 , Chunmei Chen 1 , Yan He 2 , Mengsha Wei 1 , Li Cheng 3 , Xin Kang 1 , Jianping Wang 1 , Xincai Hao 3 , Hucheng Zhu 1 , Yonghui Zhang 1
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Two undescribed prenylated quinolinone alkaloids, aspoquinolones E and F, and three undescribed prenylated isoindolinone alkaloids aspernidines F-H, were isolated from the fungus Aspergillus nidulans. Their structures and configurations were elucidated based on spectroscopic analyses and ECD spectra. Aspoquinolones E and F possess a C10 moiety with an unusual 2,2,4-trimethyl-3oxa-bicyclo[3.1.0]hexane unit, and aspernidines F-H own a C15 side chain. These compounds were evaluated for cytotoxic activities against five human cancer cell lines, compounds 1 and 5 exhibited strong inhibitory activities against A-549 and SW-480 cells with IC50 values of 3.50 and 4.77 μM, respectively.
中文翻译：
来自真菌构巢曲霉的异戊二烯化喹啉酮生物碱和异戊二烯化异吲哚啉酮生物碱
从真菌构巢曲霉中分离出两种未描述的异戊二烯化喹啉酮生物碱、aspoquinolones E 和 F，以及三种未描述的异戊二烯化异吲哚酮生物碱 aspernidines FH。基于光谱分析和 ECD 光谱阐明了它们的结构和构型。Aspoquinolones E 和 F 拥有一个 C10 部分和一个不寻常的 2,2,4-trimethyl-3oxa-bicyclo[3.1.0] 己烷单元，而 aspernidines FH 拥有一个 C15 侧链。评估了这些化合物对五种人类癌细胞系的细胞毒活性，化合物 1 和 5 对 A-549 和 SW-480 细胞表现出很强的抑制活性，IC50 值分别为 3.50 和 4.77 μM。
更新日期：2020-01-01
中文翻译：
来自真菌构巢曲霉的异戊二烯化喹啉酮生物碱和异戊二烯化异吲哚啉酮生物碱
从真菌构巢曲霉中分离出两种未描述的异戊二烯化喹啉酮生物碱、aspoquinolones E 和 F，以及三种未描述的异戊二烯化异吲哚酮生物碱 aspernidines FH。基于光谱分析和 ECD 光谱阐明了它们的结构和构型。Aspoquinolones E 和 F 拥有一个 C10 部分和一个不寻常的 2,2,4-trimethyl-3oxa-bicyclo[3.1.0] 己烷单元，而 aspernidines FH 拥有一个 C15 侧链。评估了这些化合物对五种人类癌细胞系的细胞毒活性，化合物 1 和 5 对 A-549 和 SW-480 细胞表现出很强的抑制活性，IC50 值分别为 3.50 和 4.77 μM。
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