Manganese‐Based Functional Nanoplatforms: Nanosynthetic Construction, Physiochemical Property, and Theranostic Applicability,Advanced Functional Materials

当前位置： X-MOL 学术 › Adv. Funct. Mater. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Manganese‐Based Functional Nanoplatforms: Nanosynthetic Construction, Physiochemical Property, and Theranostic Applicability
Advanced Functional Materials ( IF 18.5 ) Pub Date : 2019-11-07 , DOI: 10.1002/adfm.201907066
Xiaoqin Qian ₁ , Xiaoxia Han ₂ , Luodan Yu ₃ , Tianming Xu ₄ , Yu Chen ₃

Affiliation

Transition metal‐based nanoparticles have shown their broad applications in versatile biomedical applications. Although traditional iron‐based nanoparticles have been extensively explored in biomedicine, transition metal manganese (Mn)‐based nanoparticulate systems have emerged as a multifunctional nanoplatform with their intrinsic physiochemical property and biological effect for satisfying the strict biomedical requirements. This comprehensive review focuses on recent progress of Mn‐based functional nanoplatforms in biomedicine with the particular discussion on their elaborate construction, physiochemical property, and theranostic applicability. Several Mn‐based nanosystems are discussed in detail, including solid/hollow MnO_x nanoparticles, 2D MnO_x nanosheets, MnO_x‐silica/mesoporous silica nanoparticles, MnO_x‐Fe₃O₄ nanoparticles, MnO_x‐Au, MnO_x‐fluorescent nanoparticles, Mn‐based organic composite nanosystem, and some specific/unique Mn‐based nanocomposites. Their versatile biomedical applications include pH/reducing‐responsive T₁‐weighted positive magnetic resonance imaging, controlled drug loading/delivery/release, protection of neurological disorder, photothermal hyperthermia, photodynamic therapy, chemodynamic therapy, alleviation of tumor hypoxia, immunotherapy, and some specific synergistic therapies, which are based on their disintegration behavior under the mildly acidic/reducing condition, multiple enzyme‐mimicking activity, catalytic‐triggering Fenton reaction, etc. The biological effects and biocompatibility of these Mn‐based nanosystems are also discussed, accompanied with a discussion on challenges/critical issues and an outlook on the future developments and clinical‐translation potentials of these intriguing Mn‐based functional nanoplatforms.

中文翻译：

锰基功能纳米平台：纳米合成结构，理化性质和治疗学适用性

基于过渡金属的纳米粒子已在多种生物医学应用中显示了其广泛的应用。尽管传统的铁基纳米颗粒已在生物医学中得到了广泛的探索，但过渡金属锰（Mn）基纳米颗粒系统已成为一种多功能纳米平台，具有其固有的理化性质和生物效应，可以满足严格的生物医学要求。这项全面的综述着重于基于Mn的功能纳米平台在生物医学中的最新进展，并特别讨论了它们的精心构建，理化性质和分子筛的适用性。详细讨论了几种基于Mn的纳米系统，包括固态/空心MnO _x纳米颗粒，二维MnO _x纳米片，MnO _x二氧化硅/介孔二氧化硅纳米粒子，MnO _x ‐Fe ₃ O ₄纳米粒子，MnO _x ‐Au，MnO _x荧光纳米粒子，Mn基有机复合纳米系统和某些特定/独特的Mn基纳米复合材料。它们的多功能生物医学应用包括pH /还原反应性T ₁加权正磁共振成像，可控制的药物装载/递送/释放，神经系统疾病的保护，光热疗，光动力疗法，化学动力疗法，减轻肿瘤缺氧，免疫疗法以及一些特定的协同疗法，这取决于它们在下列条件下的崩解行为温和的酸性/还原条件，多种酶模拟活性，催化触发的Fenton反应等。还讨论了这些基于Mn的纳米系统的生物效应和生物相容性，并讨论了挑战/关键问题以及对有机物的展望。这些有趣的基于Mn的功能纳米平台的未来发展和临床翻译潜力。

更新日期：2020-01-17

点击分享查看原文

点击收藏

阅读更多本刊最新论文本刊介绍/投稿指南11