Recombinant Spider Silk-Silica Hybrid Scaffolds with Drug-Releasing Properties for Tissue Engineering Applications.,Macromolecular Rapid Communications

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Recombinant Spider Silk-Silica Hybrid Scaffolds with Drug-Releasing Properties for Tissue Engineering Applications.
Macromolecular Rapid Communications ( IF 4.2 ) Pub Date : 2019-11-07 , DOI: 10.1002/marc.201900426
Sushma Kumari ₁ , Hendrik Bargel ₁ , Thomas Scheibel _{1,

2}

Affiliation

Fabricating biomaterials with antimicrobial activity to prevent the growth of detrimental microorganisms is of great scientific and practical interest. Here, composite materials comprising recombinant spider silk proteins and mesoporous silica nanoparticles (MSN) loaded with selected antibiotics and antimycotics are fabricated into films and hydrogels. The derived composite materials exhibit excellent antimicrobial properties with sustained release of antibiotics over the course of 15 days. Furthermore, antibiotics/antimycotics inclusion does not impair the cytocompatibility of the composite materials, all of which promote fibroblast cell adhesion and proliferation. Finally, processing of spider silk-MSN composite hydrogels using 3D printing is shown to enable the fabrication of patient-specific antimicrobial implants to prevent infection in the near future.

中文翻译：

具有药物释放特性的重组蜘蛛丝-二氧化硅混合支架，用于组织工程应用。

制备具有抗微生物活性以防止有害微生物生长的生物材料具有重大的科学和实践意义。在这里，将包含重组蜘蛛丝蛋白和负载有选定抗生素和抗真菌药的中孔二氧化硅纳米粒子（MSN）的复合材料制成薄膜和水凝胶。衍生的复合材料在15天的过程中具有出色的抗菌性能，并能持续释放抗生素。此外，包含抗生素/抗真菌药不会损害复合材料的细胞相容性，所有这些都可促进成纤维细胞的粘附和增殖。最后，

更新日期：2019-11-07

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