Melatonin (N-acetyl-5-methoxy-tryptamine), which is generally considered as pleiotropic and multitasking molecule, secretes from pineal gland at night under normal light or dark conditions. Apart from circadian regulations, Melatonin also has antioxidant, anti-ageing, immunomodulation and anticancer properties. From the epidemiological research, it was postulated that Melatonin has significant apoptotic, angiogenic, oncostatic and anti-proliferative effects on various oncological cells. In this review, the underlying anticancer mechanisms of Melatonin such as stimulation of apoptosis, Melatonin receptors (MT1 and MT2) stimulation, paro-survival signal regulation, the hindering of angiogenesis, epigenetic alteration and metastasis have been discussed with recent findings. The Melatonin utilization as an adjuvant with chemotherapeutic drugs for the reinforcement of therapeutic effects was also discussed. This review precisely emphasizes the anticancer effect of Melatonin on various cancer cells. This review exemplifies the epidemiology and anticancer efficiency of Melatonin with prior attention to the mechanisms of actions.

中文翻译：

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褪黑激素及其无处不在的抗癌作用。

褪黑激素（N-acetyl-5-methoxy-tryptamine），通常被认为是多效性和多任务分子，在正常光照或黑暗条件下在夜间从松果体分泌。除了昼夜节律调节外，褪黑激素还具有抗氧化、抗衰老、免疫调节和抗癌特性。流行病学研究推测，褪黑激素对各种肿瘤细胞具有显着的凋亡、血管生成、肿瘤抑制和抗增殖作用。在这篇综述中，最近的研究结果讨论了褪黑激素的潜在抗癌机制，例如刺激细胞凋亡、褪黑激素受体（MT1 和 MT2）刺激、旁生存信号调节、阻碍血管生成、表观遗传改变和转移。还讨论了褪黑激素用作化学治疗药物的佐剂以增强治疗效果。这篇综述准确地强调了褪黑激素对各种癌细胞的抗癌作用。这篇综述举例说明了褪黑激素的流行病学和抗癌效率，并事先关注了作用机制。