The aim of this research was to develop a procedure for the synthesis of 3,4-dihydropyrimidin-2(1H)-ones under environmentally friendly conditions using alcohols as the starting materials in aqueous media. The developed protocol resulted in 3,4-dihydropyrimidin-2(1H)-ones derivatives, which are relevant intermediates with therapeutic and pharmacological properties. Target products were synthetized in a tandem process, which meets the requirements of pharmaceutical chemistry. The influence of the reaction conditions was investigated, and as a result, various substituted 3,4-dihydropyrimidin-2(1H)-ones were obtained with a yield of up to 81%, free from heavy metal impurities.

这项研究的目的是开发一种在环境友好的条件下，以醇为起始原料在水性介质中合成3,4-二氢嘧啶-2（1H）-的方法。制定的协议产生了3,4-dihydropyrimidin-2（1H）-ones衍生物，它们是具有治疗和药理特性的相关中间体。目标产物是通过串联过程合成的，这符合药物化学的要求。研究了反应条件的影响，结果获得了各种取代的3,4-二氢嘧啶-2（1H）-一，收率高达81％，不含重金属杂质。