This study assessed the presence of 27 pharmaceutically active compounds belonging to common therapeutic groups (cardiovascular, antiashmatic, psychoactive, diuretic, analgesic/anti-inflammatory, and antibiotic drugs) in the tissues of representative seafood species of bivalves, cephalopods, arthropods, and fish of high economic importance and consumption rates in North-Western Spain. Four pharmaceutical compounds, out of the 27 analyzed, were detected in the collected samples. The benzodiazepine citalopram was detected in the tissues of common octopus (14.1 ng g⁻¹ dry weight) and pod razor (9.4 ng g⁻¹ dw). The anxiolytic venlafaxine was detected in the tissues of common cockle (2.9 ng g⁻¹ dw). The veterinary antiparasitic ronidazole was found in pod razor (2.3 ng g⁻¹ dw) and, finally, the psychoactive compound alprazolam was also measured in common octopus (0.3 ng g⁻¹ dw). Hazard quotients were calculated to assess the hazard posed by the consumption of the sampled seafoods. Octopus and pod razor tissues containing citalopram and alprazolam exceeded our chosen hazard limits (HQ > 0.1) for toddlers who are high consumers of seafood (HQ values between 0.18 and 0.27). A battery of biochemical biomarkers of effects (acetylcholinesterase, glutathione S-transferase; catalase, glutathione peroxidase and glutathione reductase enzymes activities and reduced/oxidized glutathione and malondialdehyde levels) was applied to samples of the study species with the aim of characterizing their basal levels and evaluating their suitability as a tool in the monitoring chronic exposure to environmental contaminants such as those analyzed in this study. According to the measured biomarkers, pod razor and cockles have the potential to be good bioindicator species, based on the observed among-site differences detected on acetylcholinesterase, glutathione S-transferase, catalase, glutathione peroxidase activities; reduced/oxidized glutathione and malondialdehyde levels.

这项研究评估了代表性的双壳类海鲜，头足类，节肢动物和鱼类的组织中存在27种属于常见治疗组（心血管，抗灰质，精神活性，利尿剂，止痛/抗炎药和抗生素药物）的药物活性化合物在西班牙西北部具有很高的经济重要性和消费率。在收集的样品中检测到27种分析化合物中的4种药物化合物。在普通章鱼（14.1 ng g ^-1干重）和荚果剃刀（9.4 ng g ^-1 dw）的组织中检测到苯二氮卓西酞普兰。在普通鸟蛤的组织中检测到抗焦虑药文拉法辛（2.9 ng g ^-1dw）。在荚果剃刀（2.3 ng g ^-1 dw）中发现了兽用抗寄生虫药ronidazole ，最后在普通章鱼中也测定了精神活性化合物阿普唑仑（0.3 ng g ^-1dw）。计算危险商以评估食用抽样海产品造成的危险。含有西酞普兰和阿普唑仑的章鱼和豆荚剃刀组织超过了我们为海产品高消费量（HQ值在0.18至0.27之间）的幼儿选择的危害极限（HQ> 0.1）。将一系列效应的生化生物标记物（乙酰胆碱酯酶，谷胱甘肽S-转移酶；过氧化氢酶，谷胱甘肽过氧化物酶和谷胱甘肽还原酶活性以及减少/氧化的谷胱甘肽和丙二醛水平）应用于研究物种的样品，以表征其基础水平和评估其作为监测长期暴露于环境污染物（如本研究中分析的污染物）的工具的适用性。根据测得的生物标志物，根据在乙酰胆碱酯酶，谷胱甘肽S-转移酶，过氧化氢酶，谷胱甘肽过氧化物酶活性方面检测到的现场差异，荚果剃刀和鸟蛤有可能成为良好的生物指示剂。降低/氧化谷胱甘肽和丙二醛水平。