A thirty year clinical and MRI observational study of multiple sclerosis and clinically isolated syndromes,Annals of Neurology

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A thirty year clinical and MRI observational study of multiple sclerosis and clinically isolated syndromes
Annals of Neurology ( IF 8.1 ) Pub Date : 2019-11-22 , DOI: 10.1002/ana.25637
Karen K Chung ₁ , Daniel Altmann _{1,

2} , Frederik Barkhof _{1,

3,

4,

5} , Katherine Miszkiel ₆ , Peter A Brex ₇ , Jonathan O'Riordan ₈ , Michael Ebner _{4,

9,

10} , Ferran Prados _{1,

4,

11} , M Jorge Cardoso ₁₀ , Tom Vercauteren ₁₀ , Sebastien Ourselin ₁₀ , Alan Thompson _{1,

5} , Olga Ciccarelli _{1,

5} , Declan T Chard _{1,

5}

Affiliation

Nuclear Magnetic Resonance Research Unit, Queen Square Multiple Sclerosis Centre, University College London Institute of Neurology, London, United Kingdom.
Medical Statistics Department, London School of Hygiene and Tropical Medicine, London, United Kingdom.
Department of Radiology and Nuclear Medicine, Vrije University, University Medical Center, Amsterdam, the Netherlands.
Department of Medical Physics and Biomedical Engineering, Centre for Medical Image Computing, University College London, London, United Kingdom.
National Institute for Health Research, University College London Hospitals, Biomedical Research Centre, London, United Kingdom.
Lysholm Department of Neuroradiology, National Hospital of Neurology and Neurosurgery, London, United Kingdom.
King's College Hospital National Health Service Foundation Trust, London, United Kingdom.
Tayside Multiple Sclerosis Research Unit, Ninewells Hospital, Dundee, United Kingdom.
Wellcome/Engineering and Physical Sciences Research Council Centre for Interventional and Surgical Sciences, University College London, London, United Kingdom.
School of Biomedical Engineering and Imaging Sciences, King's College London, London, United Kingdom.
e-Health Centre, Open University of Catalonia, Barcelona, Spain.

Clinical outcomes in multiple sclerosis (MS) are highly variable. We aim to determine the long‐term clinical outcomes in MS, and to identify early prognostic features of these outcomes.

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