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State of the science on alternatives to animal testing and integration of testing strategies for food safety assessments: Workshop proceedings.
Regulatory Toxicology and Pharmacology ( IF 3.0 ) Pub Date : 2019-11-06 , DOI: 10.1016/j.yrtph.2019.104515
Agnes L Karmaus 1 , Heidi Bialk 2 , Suzanne Fitzpatrick 3 , Mansi Krishan 4
Affiliation  

Rapidly evolving technological methods and mechanistic toxicological understanding have paved the way for new science-based approaches for the determination of chemical safety in support of advancing public health. Approaches including read-across, high-throughput screening, in silico models, and organ-on-a-chip technologies were addressed in a 2017 workshop focusing on how scientists can move effectively toward a vision for 21st century food safety assessments. The application of these alternative methods, the need for further development of standardized practices, and the interpretation and communication of results were addressed. Expert presentations encompassed regulatory, industry, and academic perspectives, and the workshop culminated in a panel discussion in which participants engaged experts about current issues pertaining to the application of alternative methods in toxicological testing for food safety assessments.

中文翻译:

动物试验替代品的科学状况以及用于食品安全评估的试验策略的整合:研讨会程序。

迅速发展的技术方法和对机械毒理学的了解为基于科学的新方法确定化学安全性奠定了基础,以支持公共卫生的发展。2017年的研讨会讨论了包括读取,高通量筛选,计算机模型和芯片上的器官技术在内的方法,重点关注科学家如何有效地迈向21世纪食品安全评估的愿景。解决了这些替代方法的应用,对标准规范进一步发展的需求以及结果的解释和传达。专家演讲包括监管,行业和学术观点,
更新日期:2019-11-06
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