Biomimetic carbon nanotubes for neurological disease therapeutics as inherent medication.,Acta Pharmaceutica Sinica B

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Biomimetic carbon nanotubes for neurological disease therapeutics as inherent medication.
Acta Pharmaceutica Sinica B ( IF 14.7 ) Pub Date : 2019-11-06 , DOI: 10.1016/j.apsb.2019.11.003
Chenyang Xiang ₁ , Yuxuan Zhang ₂ , Weisheng Guo ₁ , Xing-Jie Liang _{1,

2}

Affiliation

Nowadays, nanotechnology is revolutionizing the approaches to different fields from manufacture to health. Carbon nanotubes (CNTs) as promising candidates in nanomedicine have great potentials in developing novel entities for central nervous system pathologies, due to their excellent physicochemical properties and ability to interface with neurons and neuronal circuits. However, most of the studies mainly focused on the drug delivery and bioimaging applications of CNTs, while neglect their application prospects as therapeutic drugs themselves. At present, the relevant reviews are not available yet. Herein we summarized the latest advances on the biomedical and therapeutic applications of CNTs in vitro and in vivo for neurological diseases treatments as inherent therapeutic drugs. The biological mechanisms of CNTs-mediated bio-medical effects and potential toxicity of CNTs were also intensely discussed. It is expected that CNTs will exploit further neurological applications on disease therapy in the near future.

中文翻译：

仿生碳纳米管作为固有药物用于神经系统疾病治疗。

如今，纳米技术正在彻底改变从制造到健康等不同领域的方法。碳纳米管（CNT）作为纳米医学中有希望的候选者，由于其优异的理化特性以及与神经元和神经元回路连接的能力，在开发中枢神经系统病理学的新型实体方面具有巨大的潜力。然而，大多数研究主要集中在碳纳米管的药物递送和生物成像应用上，而忽视了其作为治疗药物本身的应用前景。目前，尚未获得相关审查。在此，我们总结了碳纳米管作为固有治疗药物在体外和体内治疗神经系统疾病的生物医学和治疗应用的最新进展。碳纳米管介导的生物医学效应的生物学机制和碳纳米管的潜在毒性也得到了深入讨论。预计碳纳米管将在不久的将来在疾病治疗中进一步开发神经学应用。

更新日期：2019-11-06

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