Microglia and sexual differentiation of the developing brain: A focus on extrinsic factors.,Glia

当前位置： X-MOL 学术 › Glia › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Microglia and sexual differentiation of the developing brain: A focus on extrinsic factors.
Glia ( IF 5.4 ) Pub Date : 2019-11-06 , DOI: 10.1002/glia.23740
Jonathan W VanRyzin ₁ , Ashley E Marquardt ₂ , Lindsay A Pickett ₂ , Margaret M McCarthy _{1,

2}

Affiliation

Microglia, the innate immune cells of the brain, have recently been removed from the position of mere sentinels and promoted to the role of active sculptors of developing circuits and cells. Alongside their functions in normal brain development, microglia coordinate sexual differentiation of the brain, a set of processes which vary by region and endpoint like that of microglia function itself. In this review, we highlight the ways microglia are both targets and drivers of brain sexual differentiation. We examine the factors that may drive sex differences in microglia, with a special focus on how changing microenvironments in the developing brain dictate microglia phenotypes and discuss how their diverse functions sculpt lasting sex-specific changes in the brain. Finally, we consider how sex-specific early life environments contribute to epigenetic programming and lasting sex differences in microglia identity.

中文翻译：

小胶质细胞和发育中大脑的性分化：关注外在因素。

小胶质细胞是大脑的先天免疫细胞，最近已从单纯的哨兵位置中移除，并提升为开发电路和细胞的活跃雕刻者的角色。除了它们在正常大脑发育中的功能外，小胶质细胞还协调大脑的性别分化，这是一组因区域和终点而异的过程，就像小胶质细胞本身的功能一样。在这篇综述中，我们强调了小胶质细胞既是大脑性别分化的目标又是驱动因素的方式。我们研究了可能导致小胶质细胞性别差异的因素，特别关注发育中大脑中不断变化的微环境如何决定小胶质细胞表型，并讨论它们的不同功能如何塑造大脑中持久的性别特异性变化。最后，

更新日期：2019-11-06

点击分享查看原文

点击收藏

阅读更多本刊最新论文本刊介绍/投稿指南11