Interleukin-6 elevation in healthy neonates.,Journal of Perinatology

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Interleukin-6 elevation in healthy neonates.
Journal of Perinatology ( IF 2.4 ) Pub Date : 2019-11-06 , DOI: 10.1038/s41372-019-0550-3
Chinedu Ulrich Ebenebe ₁ , Andrea Boiger ₁ , Anna Perez ₁ , Franziska Lara Mathies ₂ , Kurt Hecher ₃ , Dominique Singer ₁

Affiliation

OBJECTIVE This study aimed to identify peripartum and neonatal factors associated with elevated Interleukin-6 levels in the cord blood of neonates without clinical signs of an infection. STUDY DESIGN We conducted a prospective single-center study with healthy term and preterm neonates between March and November 2017. We investigated correlations between 21 peripartum factors and neonatal IL-6 concentrations. RESULTS Four hundred and seventy-one infants (GA: 32.9-42.3 weeks) were included. The risk for elevated neonatal IL-6 levels was 3.1 to 4.5-fold increased in the presence of either peripartum maternal temperature >37.5 °C (p = 0.012), duration of labor >12 h (p < 0.001), vaginal delivery (p < 0.001), or neonatal neutrophils >8 × 109 cells/L (p < 0.001). CONCLUSION The results indicate that a considerable number of neonates with elevated IL-6 levels can sufficiently cope with an exposition to substantial perinatal stress or intrauterine inflammation and do not require postnatal antibiotic treatment.

中文翻译：

健康新生儿中白介素6升高。

目的本研究旨在确定与无临床感染迹象的新生儿脐带血中白细胞介素-6水平升高相关的围产期和新生儿因素。研究设计我们在2017年3月至11月之间对健康的足月和早产儿进行了一项前瞻性单中心研究。我们调查了21个围产期因素与新生儿IL-6浓度之间的相关性。结果纳入471例婴儿（GA：32.9-42.3周）。围产期孕产妇温度> 37.5°C（p = 0.012），分娩时间> 12 h（p <0.001），阴道分娩（p）时，新生儿IL-6水平升高的风险增加了3.1至4.5倍。 <0.001）或新生儿中性粒细胞> 8×109细胞/ L（p <0.001）。

更新日期：2019-11-06

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