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Highly Stretchable and Tough Physical Silk Fibroin-Based Double Network Hydrogels.
Macromolecular Rapid Communications ( IF 4.2 ) Pub Date : 2019-11-06 , DOI: 10.1002/marc.201900389 Yu Zhao 1 , Juan Guan 1 , Su Jun Wu 1, 2
Macromolecular Rapid Communications ( IF 4.2 ) Pub Date : 2019-11-06 , DOI: 10.1002/marc.201900389 Yu Zhao 1 , Juan Guan 1 , Su Jun Wu 1, 2
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Regenerated silk fibroin (RSF) is a promising biomedical material, but the poor mechanical properties of RSF hydrogels may hinder the use as structural components. Herein, an equilibrium RSF hydrogel is prepared and optimized based on the double network (DN) concept. After sufficient soaking in water and removal of small molecules, the equilibrium RSF DN hydrogels prove stable in water, strong, highly extensible, and tough with 0.26-0.44 MPa tensile strength, 500-900% elongation, and 2 MJ m-3 work of extension. The combination of high strength and extensibility is attributed to the homogeneous morphology and the hydrophobic interactions and hydrogen bonding between the two networks. The strategy in this work overcomes the previous issue of swelling and eventual fracture of as-prepared RSF/SDS DN hydrogels in water. In addition, such mechanically superior RSF DN hydrogels also display low cytotoxicity. It concludes that the elastic and tough RSF DN hydrogels could be engineered by introducing widely used polymer networks, and the hydrogels from inexpensive, environmentally friendly, and biocompatible silk fibroin may hold great potential in biomedical applications.
中文翻译：
高度可拉伸且坚韧的物理基于丝素蛋白的双网络水凝胶。
再生丝素蛋白（RSF）是一种有前途的生物医学材料，但是RSF水凝胶的较差的机械性能可能会阻碍其用作结构组分。在此，基于双网（DN）概念制备并优化了平衡RSF水凝胶。充分浸入水中并除去小分子后，证明平衡的RSF DN水凝胶在水中稳定，坚固，高度可延伸且坚韧，抗张强度为0.26-0.44 MPa，伸长率为500-900％，工作强度为2 MJ m-3。扩大。高强度和可扩展性的结合归因于两个网络之间的均一形态，疏水相互作用和氢键。这项工作中的策略克服了先前制备的RSF / SDS DN水凝胶在水中膨胀和最终破裂的先前问题。此外，这种机械上优越的RSF DN水凝胶也显示出低细胞毒性。结论是，可以通过引入广泛使用的聚合物网络来工程化弹性和韧性的RSF DN水凝胶，而来自廉价，环保和生物相容性丝素蛋白的水凝胶在生物医学应用中可能具有巨大的潜力。
更新日期：2019-11-06
中文翻译：
高度可拉伸且坚韧的物理基于丝素蛋白的双网络水凝胶。
再生丝素蛋白（RSF）是一种有前途的生物医学材料，但是RSF水凝胶的较差的机械性能可能会阻碍其用作结构组分。在此，基于双网（DN）概念制备并优化了平衡RSF水凝胶。充分浸入水中并除去小分子后，证明平衡的RSF DN水凝胶在水中稳定，坚固，高度可延伸且坚韧，抗张强度为0.26-0.44 MPa，伸长率为500-900％，工作强度为2 MJ m-3。扩大。高强度和可扩展性的结合归因于两个网络之间的均一形态，疏水相互作用和氢键。这项工作中的策略克服了先前制备的RSF / SDS DN水凝胶在水中膨胀和最终破裂的先前问题。此外，这种机械上优越的RSF DN水凝胶也显示出低细胞毒性。结论是，可以通过引入广泛使用的聚合物网络来工程化弹性和韧性的RSF DN水凝胶，而来自廉价，环保和生物相容性丝素蛋白的水凝胶在生物医学应用中可能具有巨大的潜力。
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