Post-translational modifications are at the apex of cellular communication and eventually regulate every aspect of life. The identification of new post-translational modifiers is opening alternative avenues in understanding fundamental cell biology processes and may ultimately provide novel therapeutic opportunities. The ubiquitin-fold modifier 1 (UFM1) is a post-translational modifier discovered a decade ago but its biological significance has remained mostly unknown. The field has recently witnessed an explosion of research uncovering the implications of the pathway to cellular homeostasis in living organisms. We overview recent advances in the function and regulation of the UFM1 pathway, and its implications for cell physiology and disease.

中文翻译：

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蛋白质变性和其他方面的UFMylation系统。

翻译后修饰是细胞通讯的最高点，并最终调节生活的各个方面。新的翻译后修饰子的识别为了解基本细胞生物学过程开辟了替代途径，并可能最终提供新的治疗机会。泛素倍修饰子1（UFM1）是十年前发现的翻译后修饰子，但其生物学意义仍然未知。该领域最近目睹了爆炸性的研究，揭示了生物体内细胞稳态的途径的意义。我们概述了UFM1通路的功能和调控的最新进展，及其对细胞生理学和疾病的影响。