Association of dietary components with dyslipidemia and low-grade inflammation biomarkers in adults with heterozygous familial hypercholesterolemia from different countries.,European Journal of Clinical Nutrition

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Association of dietary components with dyslipidemia and low-grade inflammation biomarkers in adults with heterozygous familial hypercholesterolemia from different countries.
European Journal of Clinical Nutrition ( IF 3.6 ) Pub Date : 2019-11-06 , DOI: 10.1038/s41430-019-0529-3
Luiza Antoniazzi ₁ , Raquel Arroyo-Olivares ₂ , Marcio S Bittencourt _{3,

4} , Mauricio Teruo Tada ₁ , Isabella Lima ₁ , Cinthia E Jannes ₁ , Jose E Krieger ₁ , Alexandre C Pereira ₁ , Gracia Quintana-Navarro ₅ , Ovidio Muñiz-Grijalvo ₆ , José Luís Díaz-Díaz ₇ , Daniel Zambón ₈ , Pedro Mata ₂ , Raul D Santos _{1,

9}

Affiliation

The association of components of a low saturated fat (SFA) and of a Mediterranean diet was tested with atherosclerosis biomarkers in 190 familial hypercholesterolemia adults (FH) from Brazil (BR) and Spain (SP). Median blood LDL-C, Apolipoprotein B (apoB), and C reactive protein (hs-CRP) concentrations were higher in BR than in SP: 179.0 vs.161 mg/dL; 141 vs. 103 mg/dL; and 1.6 vs. 0.8 mg/L respectively (all p < 0.001). In BR there was lower median total fat (22.3 vs. 38.3%) and SFA (8.1 vs. 12.5%) but higher cholesterol (283.3 mg vs.188.9 mg) and carbohydrate (57.1 vs. 42.5%) consumption (all p < 0.001). Inverse associations were encountered between fibers, mono, and polyunsaturated fats and their ratios to SFA with LDL-C and ApoB (all p < 0.001). There was a direct association respectively of cholesterol with lipid biomarkers and of carbohydrates and trans-fatty acids with hs-CRP while other fats showed inverse relations with the latter (p < 0.001).

中文翻译：

来自不同国家的杂合性家族性高胆固醇血症成人的饮食成分与血脂异常和低度炎症生物标志物的关联。

在巴西（BR）和西班牙（SP）的190例家族性高胆固醇血症成年人（FH）中，使用动脉粥样硬化生物标记物测试了低饱和脂肪（SFA）和地中海饮食的成分之间的关联。BR中的血液中LDL-C，载脂蛋白B（apoB）和C反应蛋白（hs-CRP）的浓度高于SP：179.0 vs.161 mg / dL。141 vs. 103 mg / dL；分别为1.6和0.8 mg / L（所有p <0.001）。在BR中，总脂肪的中位数（22.3比38.3％）和SFA（8.1比12.5％）较低，但胆固醇（283.3 mg对188.9 mg）和碳水化合物（57.1对42.5％）的摄入较高（所有p <0.001 ）。纤维，单和多不饱和脂肪及其与LDL-C和ApoB与SFA的比率之间存在负相关关系（所有p <0.001）。

更新日期：2019-11-06

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