5-Benzylidene-4-Oxazolidinones Are Synergistic with Antibiotics for the Treatment of Staphylococcus aureus Biofilms.,ChemBioChem

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5-Benzylidene-4-Oxazolidinones Are Synergistic with Antibiotics for the Treatment of Staphylococcus aureus Biofilms.
ChemBioChem ( IF 2.6 ) Pub Date : 2019-12-30 , DOI: 10.1002/cbic.201900633
Bram H Frohock _{1,

2} , Jessica M Gilbertie _{2,

3} , Jennifer C Daiker _{1,

2,

3} , Lauren V Schnabel _{2,

3} , Joshua G Pierce _{1,

2}

Affiliation

The failure of frontline antibiotics in the clinic is one of the most serious threats to human health and requires a multitude of novel therapeutics and innovative approaches to treatment so as to curtail the growing crisis. In addition to traditional resistance mechanisms resulting in the lack of efficacy of many antibiotics, most chronic and recurring infections are further made tolerant to antibiotic action by the presence of biofilms. Herein, we report an expanded set of 5-benzylidene-4-oxazolidinones that are able to inhibit the formation of Staphylococcus aureus biofilms, disperse preformed biofilms, and, in combination with common antibiotics, are able to significantly reduce the bacterial load in a robust collagen-matrix model of biofilm infection.

中文翻译：

5-苄叉基-4-恶唑烷酮类与抗生素协同治疗金黄色葡萄球菌生物膜。

前线抗生素在临床上的失败是对人类健康的最严重威胁之一，需要大量新颖的疗法和创新的治疗方法，以减少日益严重的危机。除了传统的耐药机制导致许多抗生素缺乏疗效外，由于存在生物膜，大多数慢性感染和复发性感染也被进一步耐受了抗生素的作用。在此，我们报道了一组扩展的5-亚苄基-4-恶唑烷酮，它们能够抑制金黄色葡萄球菌生物膜的形成，分散预先形成的生物膜，并与常见的抗生素结合使用，能够显着降低细菌的吸收量生物膜感染的胶原蛋白基质模型。

更新日期：2019-12-30

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