Homologated (N)-n-alkylammonium salts of 2-bromo-3-oxido-1,4-naphthoquinone (BS-1 to BS-8) have been synthesized and characterized from the single crystal X-ray diffraction experiments combined with density functional theory. The crystal structures revealed diverse noncovalent interactions such as hydrogen bonding, π∙∙∙π, Br∙∙∙π, and others. The measured antifungal activities of the BS-1 to BS-6 against fungal strains Saccharomyces cerevisiae and Candida albicans suggest them to be effective compared to standard drug amphotericin B. Antibacterial activity of BS-1 to BS-6 has been evaluated against Gram-positive and Gram-negative bacteria.

中文翻译：

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2-溴-3-氧化-1,4-萘醌的同系 (N)-n-烷基铵盐的晶体结构和生物活性

合成了 2-bromo-3-oxido-1,4-naphthoquinone（BS-1 到 BS-8）的同系 (N)-n-烷基铵盐，并从单晶 X 射线衍射实验结合密度泛函表征理论。晶体结构揭示了多种非共价相互作用，例如氢键、π∙∙∙π、Br∙∙∙π 等。BS-1 到 BS-6 对真菌菌株酿酒酵母和白色念珠菌的测量抗真菌活性表明它们与标准药物两性霉素 B 相比是有效的。 已经评估了 BS-1 到 BS-6 对革兰氏阳性菌的抗菌活性和革兰氏阴性菌。