The past two centuries have witnessed an unprecedented rise in human life expectancy. Sustaining longer lives with reduced periods of disability will require an understanding of the underlying mechanisms of ageing, and genetics is a powerful tool for identifying these mechanisms. Large-scale genome-wide association studies have recently identified many loci that influence key human ageing traits, including lifespan. Multi-trait loci have been linked with several age-related diseases, suggesting shared ageing influences. Mutations that drive accelerated ageing in prototypical progeria syndromes in humans point to an important role for genome maintenance and stability. Together, these different strands of genetic research are highlighting pathways for the discovery of anti-ageing interventions that may be applicable in humans.

中文翻译：

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人类衰老的遗传学。

过去两个世纪见证了人类预期寿命前所未有的增长。在减少残疾期的情况下维持更长的寿命将需要了解衰老的潜在机制，而遗传学是识别这些机制的有力工具。大规模全基因组关联研究最近发现了许多影响关键人类衰老特征（包括寿命）的位点。多性状基因座与几种与年龄有关的疾病有关，表明存在共同的衰老影响。驱动人类原型早衰综合征加速衰老的突变表明基因组维持和稳定具有重要作用。总之，这些不同的基因研究方向突出了发现可能适用于人类的抗衰老干预措施的途径。