HIV RNA, CD4+ Percentage, and Risk of Hepatocellular Carcinoma by Cirrhosis Status.,Journal of the National Cancer Institute

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HIV RNA, CD4+ Percentage, and Risk of Hepatocellular Carcinoma by Cirrhosis Status.
Journal of the National Cancer Institute ( IF 9.9 ) Pub Date : 2019-11-05 , DOI: 10.1093/jnci/djz214
Jessie Torgersen _{1,

2} , Michael J Kallan ₂ , Dena M Carbonari ₂ , Lesley S Park ₃ , Rajni L Mehta _{4,

5} , Kathryn D'Addeo _{4,

5} , Janet P Tate _{4,

5} , Joseph K Lim _{4,

5} , Matthew Bidwell Goetz ₆ , Maria C Rodriguez-Barradas ₇ , Cynthia L Gibert ₈ , Norbert Bräu ₉ , Sheldon T Brown ₉ , Jason A Roy ₁₀ , Tamar H Taddei _{4,

5} , Amy C Justice _{4,

5} , Vincent Lo Re _{1,

2}

Affiliation

Division of Infectious Diseases, Department of Medicine.
Department of Biostatistics, Epidemiology, and Informatics, Center for Clinical Epidemiology and Biostatistics, Center for Pharmacoepidemiology Research and Training.
Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA; Center for Population Health Sciences, Stanford University School of Medicine, Stanford, CA.
VA Connecticut Healthcare System, West Haven, CT.
Yale University School of Medicine, New Haven, CT.
VA Greater Los Angeles Healthcare System and David Geffen School of Medicine at UCLA, Los Angeles, CA.
Infectious Diseases Section, Michael E. DeBakey VA Medical Center and Department of Medicine, Baylor College of Medicine, Houston, TX.
Washington DC VA Medical Center and George Washington University Medical Center, Washington, DC.
James J. Peters VA Medical Center, Bronx, NY, and Icahn School of Medicine at Mount Sinai, New York, NY.
Department of Biostatistics, Rutgers University School of Public Health, New Brunswick, NJ.

Despite increasing incidence of hepatocellular carcinoma (HCC) among HIV-infected patients, it remains unclear if HIV-related factors contribute to development of HCC. We examined if higher or prolonged HIV viremia and lower CD4+ cell percentage were associated with HCC.

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