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Force Generation by Myosin Motors: A Structural Perspective.
Chemical Reviews ( IF 51.4 ) Pub Date : 2019-11-05 , DOI: 10.1021/acs.chemrev.9b00264 Julien Robert-Paganin 1 , Olena Pylypenko 1 , Carlos Kikuti 1 , H Lee Sweeney 2 , Anne Houdusse 1
Chemical Reviews ( IF 51.4 ) Pub Date : 2019-11-05 , DOI: 10.1021/acs.chemrev.9b00264 Julien Robert-Paganin 1 , Olena Pylypenko 1 , Carlos Kikuti 1 , H Lee Sweeney 2 , Anne Houdusse 1
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Generating force and movement is essential for the functions of cells and organisms. A variety of molecular motors that can move on tracks within cells have evolved to serve this role. How these motors interact with their tracks and how that, in turn, leads to the generation of force and movement is key to understanding the cellular roles that these motor-track systems serve. This review is focused on the best understood of these systems, which is the molecular motor myosin that moves on tracks of filamentous (F-) actin. The review highlights both the progress and the limits of our current understanding of how force generation can be controlled by F-actin-myosin interactions. What has emerged are insights they may serve as a framework for understanding the design principles of a number of types of molecular motors and their interactions with their tracks.
中文翻译：
Myosin Motors产生的力：结构的观点。
产生力和运动对于细胞和生物体的功能至关重要。可以在细胞内的轨道上移动的各种分子马达已经进化为发挥这种作用。这些电机如何与它们的轨道相互作用，以及反过来又如何导致力和运动的产生，是理解这些电机轨道系统所起的细胞作用的关键。这篇综述的重点是对这些系统的最佳理解，分子移动肌球蛋白在丝状（F-）肌动蛋白的轨道上移动。该综述突出了我们目前对如何通过F-肌动蛋白-肌球蛋白相互作用控制力产生的理解的进步和局限性。
更新日期：2019-11-05
中文翻译：
Myosin Motors产生的力：结构的观点。
产生力和运动对于细胞和生物体的功能至关重要。可以在细胞内的轨道上移动的各种分子马达已经进化为发挥这种作用。这些电机如何与它们的轨道相互作用，以及反过来又如何导致力和运动的产生，是理解这些电机轨道系统所起的细胞作用的关键。这篇综述的重点是对这些系统的最佳理解，分子移动肌球蛋白在丝状（F-）肌动蛋白的轨道上移动。该综述突出了我们目前对如何通过F-肌动蛋白-肌球蛋白相互作用控制力产生的理解的进步和局限性。
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