In this issue of Structure, Gucinski et al. (2019) have described structural and enzymatic characterizations of two tRNase ribotoxins. The study significantly advances our understanding on the evolution and the mode of action of a group of ribotoxins that cleave the accepting stem of tRNAs for cell killing.

中文翻译：

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核毒素通过切断 tRNA 的头部来杀死细胞。

在本期结构中，Gucinski 等人。（2019）描述了两种 tRNase 核毒素的结构和酶学特征。该研究显着提高了我们对一组核毒素的进化和作用模式的理解，这些核毒素切割 tRNA 的接受茎以进行细胞杀伤。