The glucocorticoid receptor (GR) has been shown to be important for mediating cellular responses to stress and circulating glucocorticoids. Ligand-dependent transcriptional changes induced by GR are observed across numerous tissues. However, the mechanisms by which GR achieves cell and tissue-specific effects are less clear. Epigenetic mechanisms have been proposed to explain some of these differences as well as some of the lasting, even transgenerational, effects of stress and glucocorticoid action. GR functions in tandem with epigenetic cellular machinery to coordinate transcription and shape chromatin structure. Here, we describe GR interactions with these effectors and how GR acts to reshape the epigenetic landscape in response to the environment.

中文翻译：

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糖皮质激素受体的表观遗传机制

糖皮质激素受体 (GR) 已被证明对于介导细胞对压力和循环糖皮质激素的反应很重要。在许多组织中观察到由 GR 诱导的配体依赖性转录变化。然而，GR 实现细胞和组织特异性作用的机制尚不清楚。已经提出表观遗传机制来解释其中一些差异以及压力和糖皮质激素作用的一些持久甚至跨代影响。GR 与表观遗传细胞机制协同工作，以协调转录和塑造染色质结构。在这里，我们描述了 GR 与这些效应器的相互作用，以及 GR 如何响应环境重塑表观遗传景观。