Mechanotransduction has a key role in vascular development, physiology, and disease states. Piezo1 is a mechanosensitive (MS) nonselective cationic channel that occurs in endothelial and vascular smooth muscle cells. It is activated by shear stress associated with increases in local blood flow, as well as by cell membrane stretch upon elevation of blood pressure. Here, we briefly review the pharmacological modulators of Piezo and discuss current understanding of the role of Piezo1 in vascular mechanobiology and associated clinical disorders, such as atherosclerosis and hypertension. Ultimately, we believe that this research will help identify novel therapeutic strategies for the treatment of vascular diseases.

中文翻译：

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心血管力学生物学中的压电离子通道。

机械转导在血管发育，生理学和疾病状态中起关键作用。Piezo1是机械敏感（MS）非选择性阳离子通道，它发生在内皮和血管平滑肌细胞中。它通过与局部血流量增加相关的剪应力以及血压升高时的细胞膜拉伸而被激活。在这里，我们简要回顾了Piezo1的药理调节剂，并讨论了目前对Piezo1在血管力学生物学和相关临床疾病（如动脉粥样硬化和高血压）中的作用的了解。最终，我们相信这项研究将有助于确定用于治疗血管疾病的新颖治疗策略。