Ion channels are critical to kidney function, and their dysregulation leads to several distinct kidney diseases. Of the diversity of ion channels in kidney cells, the transient receptor potential (TRP) superfamily of proteins plays important and varied roles in both maintaining homeostasis as well as in causing disease. Recent work showed that TRPC5 blockers could successfully protect critical components of the kidney filter both in vitro and in vivo, thus revealing TRPC5 as a tractable therapeutic target for focal and segmental glomerulosclerosis (FSGS), a common cause of kidney failure. Human genetics point to three additional TRP channels as plausible therapeutic targets: TRPC6 in FSGS, PKD2 in polycystic kidney disease, and TRPM6 in familial hypomagnesemia with secondary hypocalcemia (HSH). We conclude that targeting TRP channels could pave the way for much needed therapies for kidney diseases.

中文翻译：

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绘制TRP到肾脏疾病的新型治疗目的地。

离子通道对肾脏功能至关重要，其失调可导致几种不同的肾脏疾病。在肾细胞中离子通道的多样性中，蛋白质的瞬时受体电位（TRP）超家族在维持体内稳态以及引起疾病中都发挥着重要而多样的作用。最近的研究表明，TRPC5阻滞剂可以在体外和体内成功地保护肾脏滤器的关键组件，从而揭示出TRPC5作为局灶性和节段性肾小球硬化症（FSGS）（一种肾功能衰竭的常见原因）的易于治疗的靶标。人类遗传学指出，另外三个TRP通道是可行的治疗靶点：FSGS中的TRPC6，多囊性肾脏疾病中的PKD2和家族性低镁血症伴继发性低钙血症（HSH）的TRPM6。