The aim of this prospective investigation was to assess the association of 18F-FDG PET/CT with time to hormonal treatment failure (THTF) in men with metastatic castration-sensitive prostate cancer. Methods: 76 men with metastatic castration-sensitive prostate cancer recruited from 2005 to 2011 underwent 18F-FDG PET/CT and were followed prospectively for THTF, defined as treatment change to chemotherapy or death. Patients who had not switched to chemotherapy were censored at the last follow-up date (median of 36 mo; range, 12-108 mo). Cox regression analyses were performed to examine the association between PET/CT measurements: sum of SUVmax, maximum SUVmax, and average SUVmax for up to 10 of the most active lesions and THTF. Survival probabilities were based on the Kaplan-Meier method. Results: 43 patients had hormonal treatment failure, and 8 died without documented treatment failure. Median THTF was 26.5 mo (95% confidence interval [CI], 15.5-46.6 mo). The THTF-free probability at 5 y was 35% ± 6%. On univariate analysis, all PET parameters, including number of lesions, were statistically significant for THTF. In a reduced multivariate model accounting for clinical variables, only sum of SUVmax (hazard ratio, 1.01; 95% CI, 1.002-1.03; P = 0.024) and number of lesions (hazard ratio, 1.18; 95% CI, 1.08-1.29; P < 0.001) were independently associated with THTF. When sum of SUVmax was grouped into quartile ranges, there was a significantly worse survival probability for patients in the fourth-quartile range than in the first, with a univariate hazard ratio of 6.2 (95% CI, 2.8-13.6; P < 0.001). Conclusion: Sum of SUVmax and number of lesions derived from 18F-FDG PET/CT provide independent prognostic information on THTF in men with metastatic castration-sensitive prostate cancer.

中文翻译：

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用18F-FDG PET / CT预测转移性去势敏感性前列腺癌的激素治疗失败时间。

这项前瞻性研究的目的是评估转移性去势敏感性前列腺癌男性患者中18F-FDG PET / CT与时间与激素治疗失败（THTF）的关系。方法：2005年至2011年招募的76例转移性去势敏感性前列腺癌患者接受18F-FDG PET / CT手术，并进行前瞻性THTF随访，定义为化疗或死亡。在最后的随访日期（中位数为36 mo；范围为12-108 mo），未接受化疗的患者将接受检查。进行了Cox回归分析以检查PET / CT测量值之间的关联：SUVmax，最大SUVmax和最多10个最活跃病灶和THTF的平均SUVmax之和。生存概率基于Kaplan-Meier方法。结果：43例激素治疗失败，另有8人死亡，但未记录治疗失败。THTF中位数为26.5 mo（95％置信区间[CI]，15.5-46.6 mo）。5年无THTF的概率为35％±6％。单因素分析显示，所有PET参数（包括病变数目）对于THTF均具有统计学意义。在考虑临床变量的简化多元模型中，仅SUVmax（危险比，1.01； 95％CI，1.002-1.03； P = 0.024）和病变数目（危险比，1.18； 95％CI，1.08-1.29；总和）相加。 P <0.001）与THTF独立相关。如果将SUVmax的总和分为四分位数范围，则第四四分位数范围的患者的生存概率显着低于第一四分位数范围的患者，其单因素风险比为6.2（95％CI，2.8-13.6； P <0.001） 。结论：