CD20‐positive T‐cell lymphoma (TCL) is a very rare disease entity that is associated with the co‐expressions of a range of T cell lineage makers, such as, CD2, CD3, CD5, or CD7, and CD20. The biological and clinical significance of CD20 antigen expressed in TCL has been unclear. Here, we are reporting an unusual case of CD20‐positive primary nasal peripheral T‐cell lymphoma, not otherwise specified (PTCL‐NOS) in a 62‐year‐old female with both peripheral blood (PB) and bone marrow (BM) involvement. Flow cytometry (FC) analysis revealed CD20+ lymphoma cells in PB, BM, and lymph node (LN) and was consistent with pathological findings. FC immunophenotyping was proved of great diagnostic contribution.

中文翻译：

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CD20阳性原发性鼻外周T细胞淋巴瘤1例分析并文献复习。

CD20 阳性 T 细胞淋巴瘤 (TCL) 是一种非常罕见的疾病实体，与一系列 T 细胞谱系标记物（如 CD2、CD3、CD5 或 CD7 和 CD20）的共表达有关。TCL 中表达的 CD20 抗原的生物学和临床意义尚不清楚。在这里，我们报告了一例罕见的 CD20 阳性原发性鼻外周 T 细胞淋巴瘤，未另作说明 (PTCL-NOS)，患者为外周血 (PB) 和骨髓 (BM) 受累的 62 岁女性. 流式细胞术 (FC) 分析显示 PB、BM 和淋巴结 (LN) 中存在 CD20+ 淋巴瘤细胞，并且与病理结果一致。FC 免疫表型被证明具有巨大的诊断贡献。