MR fingerprinting ASL: Sequence characterization and comparison with dynamic susceptibility contrast (DSC) MRI.,NMR in Biomedicine

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MR fingerprinting ASL: Sequence characterization and comparison with dynamic susceptibility contrast (DSC) MRI.
NMR in Biomedicine ( IF 2.7 ) Pub Date : 2019-11-04 , DOI: 10.1002/nbm.4202
Pan Su _{1,

2} , Hongli Fan _{1,

3} , Peiying Liu ₁ , Yang Li _{1,

2} , Ye Qiao ₁ , Jun Hua _{1,

3,

4} , Doris Lin ₁ , Dengrong Jiang _{1,

3} , Jay J Pillai _{1,

5} , Argye E Hillis _{6,

7,

8} , Hanzhang Lu _{1,

3,

4}

Affiliation

MR Fingerprinting (MRF)-based Arterial-Spin-Labeling (ASL) has the potential to measure multiple parameters such as cerebral blood flow (CBF), bolus arrival time (BAT), and tissue T1 in a single scan. However, the previous reports have only demonstrated a proof-of-principle of the technique but have not examined the performance of the sequence in the context of key imaging parameters. Furthermore, there has not been a study to directly compare the technique to clinically used perfusion method of dynamic-susceptibility-contrast (DSC) MRI. The present report consists of two studies. In the first study (N = 8), we examined the dependence of MRF-ASL sequence on TR time pattern. Ten different TR patterns with a range of temporal characteristics were examined by both simulations and experiments. The results revealed that there was a significance dependence of the sequence performance on TR pattern (p < 0.001), although there was not a single pattern that provided dramatically improvements. Among the TR patterns tested, a sinusoidal pattern with a period of 125 TRs provided an overall best estimation in terms of spatial consistency. These experimental observations were consistent with those of numerical simulations. In the second study (N = 8), we compared MRF-ASL results with those of DSC MRI. It was found that MRF-ASL and DSC MRI provided highly comparable maps of cerebral blood flow (CBF) and bolus-arrival-time (BAT), with spatial correlation coefficients of 0.79 and 0.91, respectively. However, in terms of quantitative values, BAT obtained with MRF-ASL was considerably lower than that from DSC (p < 0.001), presumably because of the differences in tracer characteristics in terms of diffusible versus intravascular tracers. Test-retest assessment of MRF-ASL MRI revealed that the spatial correlations of parametric maps were 0.997, 0.962, 0.746 and 0.863 for B1 + , T1 , CBF, and BAT, respectively. MRF-ASL is a promising technique for assessing multiple perfusion parameters simultaneously without contrast agent.

中文翻译：

MR 指纹 ASL：序列表征以及与动态磁化率对比 (DSC) MRI 的比较。

基于 MR 指纹 (MRF) 的动脉自旋标记 (ASL) 具有在单次扫描中测量多个参数的潜力，例如脑血流量 (CBF)、推注到达时间 (BAT) 和组织 T1。然而，之前的报告仅展示了该技术的原理验证，但没有在关键成像参数的背景下检查序列的性能。此外，还没有一项研究直接将该技术与临床使用的动态磁敏感对比（DSC）MRI 灌注方法进行比较。本报告由两项研究组成。在第一项研究 (N = 8) 中，我们检查了 MRF-ASL 序列对 TR 时间模式的依赖性。通过模拟和实验检查了具有一系列时间特征的十种不同的 TR 模式。结果表明，序列性能对 TR 模式有显着依赖性 (p < 0.001)，尽管没有单一模式提供显着的改进。在测试的 TR 模式中，周期为 125 个 TR 的正弦模式提供了空间一致性方面的总体最佳估计。这些实验观察结果与数值模拟的结果一致。在第二项研究 (N = 8) 中，我们将 MRF-ASL 结果与 DSC MRI 结果进行了比较。结果发现，MRF-ASL 和 DSC MRI 提供了高度可比的脑血流 (CBF) 和推注到达时间 (BAT) 图，空间相关系数分别为 0.79 和 0.91。然而，就定量值而言，使用 MRF-ASL 获得的 BAT 远低于 DSC 获得的 BAT (p < 0.001)，这可能是因为扩散示踪剂与血管内示踪剂的示踪特性存在差异。 MRF-ASL MRI 的重测评估显示，B1 + 、T1 、CBF 和 BAT 参数图的空间相关性分别为 0.997、0.962、0.746 和 0.863。 MRF-ASL 是一种无需造影剂即可同时评估多个灌注参数的有前途的技术。

更新日期：2019-12-20

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