Synthesis and Hierarchical Self-Assembly of Diphenylalanine-Based Homopolymer and Copolymers By RAFT Polymerization,Journal of Polymer Science Part A: Polymer Chemistry

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Synthesis and Hierarchical Self-Assembly of Diphenylalanine-Based Homopolymer and Copolymers By RAFT Polymerization
Journal of Polymer Science Part A: Polymer Chemistry Pub Date : 2019-11-04 , DOI: 10.1002/pola.29531
Ryo Yonenuma ₁ , Ai Ishizuki ₂ , Kazuhiro Nakabayashi ₁ , Hideharu Mori _{1,

2}

Affiliation

Dipeptide diphenylalanine has attracted significant research interests because of its ability to self-assemble into various nanostructures such as nanotubes, nanowires, and nanoribbons. In this article, we present the synthesis and self-assembly of a novel diphenylalanine-based homopolymer and block/random copolymers by the reversible addition–fragmentation chain transfer (RAFT) polymerization of an acrylamide having a dipeptide moiety. The RAFT polymerization of N-acryloyl-l,l-diphenylalanine (A-Phe-Phe-OH) afforded novel amino acid-based polymers with predetermined molecular weights and relatively narrow-molecular weight distributions. The hierarchical self-assembled structures of poly(A-Phe-Phe-OH), which involve nanorods, larger nanofiber-like microcrystals, and fiber bundles, were characterized by atomic force microscopy (AFM), transmission electron microscopy, scanning electron microscopy, and dynamic light scattering measurements. The circular dichroic measurements of poly(A-Phe-Phe-OH) revealed its characteristic chiroptical property, which is affected by the nature of the solvents and the addition of urea and salts via hydrophobic, hydrogen bonding, and electrostatic interactions. Thermo- and pH-responsive block and random copolymers composed of A-Phe-Phe-OH and N-isopropylacrylamide were synthesized by RAFT polymerization, and the thermoresponsive properties and assembled structures of the resulting copolymers were investigated by AFM and turbidity measurements. © 2019 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2019, 57, 2562–2574

中文翻译：

RAFT聚合法合成和分级自组装二苯丙氨酸基均聚物和共聚物

二肽二苯丙氨酸因其能够自组装成各种纳米结构（如纳米管、纳米线和纳米带）而引起了广泛的研究兴趣。在本文中，我们介绍了一种新型二苯丙氨酸基均聚物和嵌段/无规共聚物的合成和自组装，方法是通过具有二肽部分的丙烯酰胺的可逆加成-断裂链转移 (RAFT) 聚合。N-丙烯酰-l、l的RAFT聚合-二苯丙氨酸 (A-Phe-Phe-OH) 提供了具有预定分子量和相对窄的分子量分布的新型氨基酸基聚合物。聚（A-Phe-Phe-OH）的分层自组装结构，包括纳米棒、较大的纳米纤维状微晶和纤维束，通过原子力显微镜（AFM）、透射电子显微镜、扫描电子显微镜、和动态光散射测量。聚 (A-Phe-Phe-OH) 的圆二向色测量揭示了其特有的手性特性，该特性受溶剂性质以及通过疏水、氢键和静电相互作用添加尿素和盐的影响。由 A-Phe-Phe-OH 和N组成的热响应和 pH 响应嵌段和无规共聚物通过RAFT聚合合成-异丙基丙烯酰胺，并通过AFM和浊度测量研究所得共聚物的热响应性能和组装结构。© 2019 Wiley Periodicals, Inc. J. Polym。科学，A 部分：Polym。化学。2019 , 57 , 2562–2574

更新日期：2019-11-04

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