Pathway‐based differential expression analysis allows the incorporation of biological domain knowledge into transcriptomics analysis to enhance our understanding of disease mechanisms. To integrate information among multiple studies at the pathway level, pathway‐based meta‐analysis can be performed. Paired or partially paired samples are common in biomedical research. However, there are currently no existing pathway‐based meta‐analysis methods appropriate for paired or partially paired study designs.

中文翻译：

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基于路径的荟萃分析，用于部分配对的转录组学分析。

基于途径的差异表达分析可将生物学领域的知识整合到转录组学分析中，以增进我们对疾病机制的了解。为了在途径水平上整合多个研究之间的信息，可以进行基于途径的荟萃分析。成对或部分成对的样品在生物医学研究中很常见。但是，目前尚无适用于成对或部分成对研究设计的基于途径的荟萃分析方法。