Lipid-based drug delivery systems (LBDDS) are highly relevant as pharmaceutical formulations significantly enhancing the bioavailability of active pharmaceutical ingredients (APIs). These formulations often are complex mixtures of APIs, various lipids, and other excipients (e.g. surfactants). In their simplest form, LBDDS contain one API being dissolved in a pure lipid, which often is a triglyceride (TG). In this work, solubilities of the APIs indomethacin, ibuprofen, and fenofibrate in pure TGs of different chain lengths (C chain 8–18) and degree of saturation were investigated. Solubilities of APIs in TGs were measured via differential scanning calorimetry, hot-stage microscopy, high-performance liquid chromatography, and Raman spectroscopy. The influence of fatty-acid chain length and degree of saturation on the API solubility in the TGs was investigated. APIs showed a higher solubility in saturated (w_IBU = 10.5 wt% at 25 °C in tricaprylin) TGs compared to unsaturated ones (w_IBU = 4.0 wt% at 25 °C in triolein). The fatty-acid chain length of TGs only slightly affects the solubility of ibuprofen and fenofibrate, but strongly influences the eutectic temperature of the API/TG mixtures.

API solubilities in TGs and TG mixtures (mixtures of tricaprylin and tricaprin) were successfully modeled using the Perturbed-Chain Statistical Associating Fluid Theory (PC-SAFT) accounting for the intermolecular API/TG interactions providing a deep understanding of the energetic and structural impact of the TGs on API solubility.

基于脂质的药物输送系统（LBDDS）与药物制剂高度相关，因为药物制剂可显着提高活性药物成分（API）的生物利用度。这些制剂通常是API，各种脂质和其他赋形剂（例如表面活性剂）的复杂混合物。以最简单的形式，LBDDS包含一个溶解在纯脂质中的API，该脂质通常是甘油三酸酯（TG）。在这项工作中，研究了吲哚美辛，布洛芬和非诺贝特原料药在不同链长（C链8-18）和饱和度的纯TG中的溶解度。通过差示扫描量热法，热台显微镜检查，高效液相色谱和拉曼光谱法测量API在TG中的溶解度。研究了脂肪酸链长和饱和度对TGs中API溶解度的影响。API显示出较高的饱和溶解度（w 与不饱和 甘油三酸酯相比，甘油三辛酸酯中_IBU =在25°C时为10.5 wt％（TG在25°C中三油精中，而_IBU = 4.0 wt％）。TG的脂肪酸链长度仅轻微影响布洛芬和非诺贝特的溶解度，但对API / TG混合物的低共熔温度有很大影响。

使用扰动链统计缔合流体理论（PC-SAFT）成功地模拟了TG和TG混合物（三辛精和三辛精的混合物）中的API溶解度，解释了API / TG的分子间相互作用，从而深入了解了API的能量和结构影响TG对API溶解度的影响。