Neurodegenerative diseases, such as Alzheimer's and Parkinson's, are considered prion-like disorders because they are all proteinopathies in which aberrant proteins spread throughout the brain during disease progression. The overall aim of this study is to determine how glial cells are commonly involved in the neurodegeneration progress observed in all these pathologies. The suggestion that they are cell types in which prion and prion-like disorders have common behaviour is the hypothesis on which this study is based. Morphological and distribution differences in astroglial and microglial cells in the cerebellum from prion and prion-like disease-affected patients were assessed here by histopathological and immunochemical tools. To our knowledge, this is the first study to focus on the comparative assessment of glial profiles in these human brains. Activated microglial population was demonstrated in both, prion and prion-like disorders, although in higher extent in the first. In astroglial activation, specific patterns of alterations suggesting both degenerative and potentially neuroprotective or restorative stem cell response, were shown to be alternatively shared by cerebella from all disorders studied. Neuro-protective strategies for these disabling disorders are particularly desirable.

中文翻译：

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gli病毒和ion病毒样疾病患者的小脑共享神经胶质模式。

神经退行性疾病，例如阿尔茨海默氏病和帕金森氏病，被认为是病毒样疾病，因为它们都是蛋白质病，在疾病发展过程中，异常蛋白会散布在整个大脑中。这项研究的总体目的是确定在所有这些病理中观察到的神经变性进展中神经胶质细胞通常是如何参与的。认为它们是cell病毒和病毒样疾病具有共同行为的细胞类型是这项研究基于的假设。在这里，通过组织病理学和免疫化学工具评估了病毒和and病毒样疾病患者的小脑星形胶质细胞和小胶质细胞的形态和分布差异。据我们所知，这是第一项专注于这些人脑中神经胶质分布的比较评估的研究。在病毒和病毒样疾病中均显示了活化的小胶质细胞种群，尽管在第一个病例中程度较高。在星形胶质细胞激活中，表明变性的和潜在的神经保护性或恢复性干细胞反应的特定改变模式，被小脑在所有研究的疾病中交替存在。对于这些致残障碍的神经保护策略是特别期望的。结果表明，所有研究的疾病均与小脑共享。对于这些致残障碍的神经保护策略是特别期望的。结果表明，所有研究的疾病均与小脑共享。对于这些致残障碍的神经保护策略是特别期望的。