The aim of this study is to analyse the of expression levels of microRNA-200 family members in patients with metastatic clear cell renal cell carcinoma (ccRCC). Analysis of microRNA expression was performed on 23 paired DNA samples extracted from kidney tumour tissue and the surrounding normal renal parenchyma. MicroRna-200c was found to have significantly lower expression (in kidney tumour tissue compared to normal renal parenchyma. No other microRna-200 family members showed statistically significant differences in expression levels between tumour and normal kidney tissue. Recent data suggest that the role of microRNA-200c in tumour pathogenesis is rather contradictory, and the underlying mechanisms by which microRNA-200c affects the carcinogenic potential of malignant cells remains unclear and requires further investigation at the molecular level.

本研究的目的是分析转移性透明细胞肾细胞癌 (ccRCC) 患者中 microRNA-200 家族成员的表达水平。对从肾脏肿瘤组织和周围正常肾实质中提取的 23 对 DNA 样本进行了 microRNA 表达分析。发现 MicroRna-200c 的表达显着降低（与正常肾实质相比，在肾肿瘤组织中。没有其他 microRna-200 家族成员在肿瘤和正常肾组织之间的表达水平上表现出统计学上的显着差异。最近的数据表明 microRNA 的作用-200c在肿瘤发病机制中是相当矛盾的，