Clearance of cerebrospinal fluid from the sacral spine through lymphatic vessels.,Journal of Experimental Medicine

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Clearance of cerebrospinal fluid from the sacral spine through lymphatic vessels.
Journal of Experimental Medicine ( IF 12.6 ) Pub Date : 2019-08-27 , DOI: 10.1084/jem.20190351
Qiaoli Ma ₁ , Yann Decker ₂ , Andreas Müller ₃ , Benjamin V Ineichen ₄ , Steven T Proulx _{5,

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Affiliation

The pathways of circulation and clearance of cerebrospinal fluid (CSF) in the spine have yet to be elucidated. We have recently shown with dynamic in vivo imaging that routes of outflow of CSF in mice occur along cranial nerves to extracranial lymphatic vessels. Here, we use near-infrared and magnetic resonance imaging to demonstrate the flow of CSF tracers within the spinal column and reveal the major spinal pathways for outflow to lymphatic vessels in mice. We found that after intraventricular injection, a spread of CSF tracers occurs within both the central canal and the spinal subarachnoid space toward the caudal end of the spine. Outflow of CSF tracers from the spinal subarachnoid space occurred predominantly from intravertebral regions of the sacral spine to lymphatic vessels, leading to sacral and iliac LNs. Clearance of CSF from the spine to lymphatic vessels may have significance for many conditions, including multiple sclerosis and spinal cord injury.

中文翻译：

通过淋巴管从骶骨清除脑脊液。

脊柱中脑脊液（CSF）的循环和清除途径尚未阐明。我们最近通过动态体内成像表明，小鼠脑脊液的流出路径沿着颅神经至颅外淋巴管。在这里，我们使用近红外和磁共振成像来演示脑脊液示踪剂在脊柱内的流动，并揭示小鼠流出淋巴管的主要脊柱通路。我们发现，脑室内注射后，脑脊液示踪剂会在中央管和脊柱蛛网膜下腔内向脊柱尾端扩散。脑脊液示踪剂从脊髓蛛网膜下腔的流出主要发生在从骶棘的椎内区域流向淋巴管，导致骶骨和髂淋巴结。脑脊液从脊柱到淋巴管的清除可能对许多疾病具有重要意义，包括多发性硬化症和脊髓损伤。

更新日期：2019-11-04

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