Gasdermins and their role in immunity and inflammation.,Journal of Experimental Medicine

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Gasdermins and their role in immunity and inflammation.
Journal of Experimental Medicine ( IF 12.6 ) Pub Date : 2019-09-23 , DOI: 10.1084/jem.20190545
Pontus Orning _{1,

2} , Egil Lien _{1,

2} , Katherine A Fitzgerald _{2,

3}

Affiliation

The gasdermins are a family of pore-forming proteins recently implicated in the immune response. One of these proteins, gasdermin D (GSDMD), has been identified as the executioner of pyroptosis, an inflammatory form of lytic cell death that is induced upon formation of caspase-1-activating inflammasomes. The related proteins GSDME and GSDMA have also been implicated in autoimmune diseases and certain cancers. Most gasdermin proteins are believed to have pore-forming capabilities. The best-studied member, GSDMD, controls the release of the proinflammatory cytokines IL-1ß and IL-18 and pyroptotic cell death. Because of its potential as a driver of inflammation in septic shock and autoimmune diseases, GSDMD represents an attractive drug target. In this review, we discuss the gasdermin proteins with particular emphasis on GSDMD and its mechanism of action and biological significance.

中文翻译：

胃泌素及其在免疫和炎症中的作用。

胃泌素是最近与免疫反应有关的成孔蛋白家族。这些蛋白质之一，即加德敏D（GSDMD），已被确定为发烧的执行者，发烧是一种裂解型细胞死亡的炎症形式，在激活caspase-1的炎症小体形成后被诱导。相关的蛋白质GSDME和GSDMA也与自身免疫性疾病和某些癌症有关。据信大多数加德明蛋白具有成孔能力。研究最深入的成员GSDMD控制促炎细胞因子IL-1ß和IL-18的释放以及焦细胞凋亡。由于GSDMD可能是感染性休克和自身免疫性疾病中炎症的驱动因素，因此它是有吸引力的药物靶标。在这篇评论中，

更新日期：2019-11-04

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