Hepatocyte-stellate cell synapse in alcohol-induced steatosis: another role for endocannabinoids.,Nature Reviews Gastroenterology & Hepatology

当前位置： X-MOL 学术 › Nat. Rev. Gastroenterol. Hepatol. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Hepatocyte-stellate cell synapse in alcohol-induced steatosis: another role for endocannabinoids.
Nature Reviews Gastroenterology & Hepatology ( IF 45.9 ) Pub Date : 2020-01-01 , DOI: 10.1038/s41575-019-0233-8
Josepmaria Argemi ₁ , Ramon Bataller ₁

Affiliation

A new study demonstrates a novel role for an endocannabinoid in promoting hepatocyte steatosis. The study describes a mode of bidirectional communication between the alcohol-injured hepatocyte and the glutamate-activated hepatic stellate cell. This intercellular communication represents a novel targetable pathogenic mechanism that could lead to new strategies to prevent fatty liver disease progression to cirrhosis.

中文翻译：

酒精诱导的脂肪变性中的肝细胞星状细胞突触：内源性大麻素的另一个作用。

一项新的研究证明了内源性大麻素在促进肝细胞脂肪变性方面的新作用。该研究描述了酒精损伤的肝细胞和谷氨酸激活的肝星状细胞之间的双向通讯模式。这种细胞间通讯代表了一种新的靶向致病机制，可以导致预防脂肪肝疾病进展为肝硬化的新策略。

更新日期：2019-11-04

点击分享查看原文

点击收藏

阅读更多本刊最新论文本刊介绍/投稿指南11