Alginate Hydrogels as Scaffolds and Delivery Systems to Repair the Damaged Spinal Cord.,Biotechnology Journal

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Alginate Hydrogels as Scaffolds and Delivery Systems to Repair the Damaged Spinal Cord.
Biotechnology Journal ( IF 3.2 ) Pub Date : 2019-11-14 , DOI: 10.1002/biot.201900275
Santiago Grijalvo _{1,

2} , Manuel Nieto-Díaz ₃ , Rodrigo M Maza ₃ , Ramón Eritja _{1,

2} , David Díaz Díaz _{4,

5}

Affiliation

Alginate (ALG) is a lineal hydrophilic polysaccharide present in brown algae cell walls, which turns into a gel state when hydrated. Gelation readily produces a series of three dimensional (3D) architectures like fibers, capillaries, and microspheres, used as biosensors and bio-actuators in a plethora of biomedical applications like drug delivery and wound healing. Hydrogels have made a great impact on regenerative medicine and tissue engineering because they are able to mimic the mechanical properties of natural tissues due to their high water content. Recent advances in neurosciences have led to promising strategies for repairing and/or regenerating the damaged nervous system. Spinal cord injury (SCI) is particularly challenging, owing to its devastating medical, human, and social consequences. Although effective therapies to repair the damaged spinal cord (SC) are still lacking, multiple pharmacological, genetic, and cell-based therapies are currently under study. In this framework, ALG hydrogels constitute a source of potential tools for the development of implants capable of promoting axonal growth and/or delivering cells or drugs at specific damaged sites, which may result in therapeutic strategies for SCI. In this mini-review, the current state of the art of ALG applications in neural tissues for repairing the damaged spinal cord is discussed.

中文翻译：

海藻酸盐水凝胶作为修复受损脊髓的支架和输送系统。

海藻酸盐（ALG）是存在于褐藻细胞壁中的一种线型亲水性多糖，水合后会变成凝胶状态。凝胶化很容易产生一系列三维（3D）结构，例如纤维，毛细血管和微球，在众多生物医学应用（例如药物输送和伤口愈合）中用作生物传感器和生物致动器。水凝胶对再生医学和组织工程产生了巨大的影响，因为它们具有很高的水含量，因此能够模仿天然组织的机械性能。神经科学的最新进展已导致修复和/或再生受损神经系统的有前途的策略。脊髓损伤（SCI）由于具有毁灭性的医学，人类和社会后果，尤其具有挑战性。尽管仍然缺乏修复受损脊髓（SC）的有效疗法，但目前仍在研究多种药理，遗传和基于细胞的疗法。在此框架中，ALG水凝胶构成了潜在的工具，用于开发能够促进轴突生长和/或在特定受损部位递送细胞或药物的植入物，这可能会导致SCI的治疗策略。在此小型审查中，将讨论ALG在神经组织中修复受损脊髓的应用的当前技术水平。ALG水凝胶构成了潜在的工具，用于开发能够促进轴突生长和/或在特定受损部位递送细胞或药物的植入物，这可能会导致SCI的治疗策略。在此小型审查中，将讨论ALG在神经组织中修复受损脊髓的应用的当前技术水平。ALG水凝胶构成了潜在的工具，用于开发能够促进轴突生长和/或在特定受损部位递送细胞或药物的植入物，这可能会导致SCI的治疗策略。在此小型审查中，将讨论ALG在神经组织中修复受损脊髓的应用的当前技术水平。

更新日期：2019-11-14

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