Chemotherapeutic drugs may disrupt the nervous system and cause chemotherapy-induced peripheral neuropathy (CIPN) as side effects. There are no completely successful medications for the prevention or treatment of CIPN. Many drugs such as tricyclic antidepressants and anticonvulsants have been used for symptomatic treatment of CIPN. Unfortunately, these drugs often give only partial relief or have dose-limiting side effects. Thus, the treatment of CIPN becomes a challenge because of failure to regenerate and repair the injured neurons. Mesenchymal stem cell (MSC) therapy is a new attractive approach for CIPN. Evidence has demonstrated that MSCs play important roles in reducing oxidative stress, neuroinflammation, and apoptosis, as well as mediating axon regeneration after nerve damage in several experimental studies and some clinical trials. We will briefly review the pathogenesis of CIPN, traditional therapies used and their drawbacks as well as therapeutic effects of MSCs, their related mechanisms, future challenges for their clinical application, and the additional benefit of their combination with pharmacological agents. MSCs-based therapies may provide a new therapeutic strategy for patients suffering from CIPN where further investigations are required for studying their exact mechanisms. Combined therapy with pharmacological agents can provide another promising option for enhancing MSC therapy success while limiting its adverse effects.

中文翻译：

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化疗诱导的周围神经病中的间充质干细胞：一种新的具有挑战性的方法，需要进一步研究。

化疗药物可能会破坏神经系统，并引起化疗引起的周围神经病变（CIPN）。没有完全成功的药物可以预防或治疗CIPN。三环类抗抑郁药和抗惊厥药等许多药物已用于CIPN的对症治疗。不幸的是，这些药物通常只能部分缓解或具有剂量限制的副作用。因此，由于不能再生和修复受伤的神经元，CIPN的治疗成为一个挑战。间充质干细胞（MSC）治疗是CIPN的一种新的有吸引力的方法。有证据表明，在一些实验研究和一些临床试验中，MSC在减少氧化应激，神经炎症和细胞凋亡以及介导神经损伤后的轴突再生中起着重要作用。我们将简要回顾一下CIPN的发病机理，使用的传统疗法及其缺点以及MSC的治疗效果，它们的相关机制，其临床应用的未来挑战以及它们与药理学药剂的结合所带来的其他好处。基于MSCs的疗法可能为患有CIPN的患者提供一种新的治疗策略，需要进一步研究以研究其确切机制。药物治疗与联合疗法可提供另一种有希望的选择，以增强MSC治疗的成功率，同时限制其不良反应。以及它们与药理学药剂结合使用的额外好处。基于MSCs的疗法可能为患有CIPN的患者提供一种新的治疗策略，需要进一步研究以研究其确切机制。药物疗法与联合疗法可以提供另一种有希望的选择，以增强MSC治疗的成功率，同时限制其不良反应。以及它们与药理学药剂结合使用的额外好处。基于MSCs的疗法可能为患有CIPN的患者提供一种新的治疗策略，需要进一步研究以研究其确切机制。药物治疗与联合疗法可提供另一种有希望的选择，以增强MSC治疗的成功率，同时限制其不良反应。